DEPs Induce Local Ige Class Switching Independent of Their Ability to Stimulate IBALT De Novo Formation

Overview

Journal Int J Environ Res Public Health

Publisher MDPI

Specialties Environmental Health
Public Health

Date 2022 Oct 27

PMID 36293642

Authors

Dmitrii Borisovich Chudakov

Mariya Vladimirovna Konovalova

Elena Igorevna Kashirina

Olga Dmitrievna Kotsareva

Marina Alexandrovna Shevchenko

Daria Sergeevna Tsaregorodtseva

Gulnar Vaisovna Fattakhova

Affiliations

Soon will be listed here.

Abstract

Background: Diesel exhaust particles (DEPs) are leading to a general increase in atopic diseases worldwide. However, it is still unknown whether DEPs induce systemic B-cell IgE class switching in secondary lymphoid organs or locally in the lungs in inducible bronchus-associated lymphoid tissue (iBALT). The aim of this work was to identify the exact site of DEP-mediated B-cell IgE class switching and pro-allergic antibody production.

Methods: We immunized BALB/c mice with different OVA doses (0.3 and 30 µg) intranasally in the presence and absence of two types of DEPs, SRM1650B and SRM2786. We used low (30 µg) and high (150 µg) DEP doses.

Results: Only a high DEP dose induced IgE production, regardless of the particle type. Local IgE class switching was stimulated upon treatment with both types of particles with both low and high OVA doses. Despite the similar ability of the two standard DEPs to stimulate IgE production, their ability to induce iBALT formation and growth was markedly different upon co-administration with low OVA doses.

Conclusions: DEP-induced local IgE class switching takes place in preexisting iBALTs independent of de novo iBALT formation, at least in the case of SRM1650B co-administered with low OVA doses.

References

Liu X, Wang J, Fan Y, Xu Y, Xie M, Yuan Y . Particulate Matter Exposure History Affects Antioxidant Defense Response of Mouse Lung to Haze Episodes. Environ Sci Technol. 2019; 53(16):9789-9799. DOI: 10.1021/acs.est.9b01068. View

Brandt E, Bolcas P, Ruff B, Khurana Hershey G . IL33 contributes to diesel pollution-mediated increase in experimental asthma severity. Allergy. 2020; 75(9):2254-2266. PMC: 7347449. DOI: 10.1111/all.14181. View

Brandt E, Biagini Myers J, Acciani T, Ryan P, Sivaprasad U, Ruff B . Exposure to allergen and diesel exhaust particles potentiates secondary allergen-specific memory responses, promoting asthma susceptibility. J Allergy Clin Immunol. 2015; 136(2):295-303.e7. PMC: 4530081. DOI: 10.1016/j.jaci.2014.11.043. View

Corrado A, Ramonell R, Woodruff M, Tipton C, Wise S, Levy J . Extrafollicular IgD+ B cells generate IgE antibody secreting cells in the nasal mucosa. Mucosal Immunol. 2021; 14(5):1144-1159. PMC: 8160425. DOI: 10.1038/s41385-021-00410-w. View

Pandya R, Solomon G, Kinner A, Balmes J . Diesel exhaust and asthma: hypotheses and molecular mechanisms of action. Environ Health Perspect. 2002; 110 Suppl 1:103-12. PMC: 1241152. DOI: 10.1289/ehp.02110s1103. View

Van Hoecke L, Job E, Saelens X, Roose K . Bronchoalveolar Lavage of Murine Lungs to Analyze Inflammatory Cell Infiltration. J Vis Exp. 2017; (123). PMC: 5607888. DOI: 10.3791/55398. View

Chudakov D, Ryasantsev D, Tsaregorotseva D, Kotsareva O, Fattakhova G, Svirshchevskaya E . Tertiary lymphoid structure related B-cell IgE isotype switching and secondary lymphoid organ linked IgE production in mouse allergy model. BMC Immunol. 2020; 21(1):45. PMC: 7412793. DOI: 10.1186/s12865-020-00376-7. View

Benezech C, Luu N, Walker J, Kruglov A, Loo Y, Nakamura K . Inflammation-induced formation of fat-associated lymphoid clusters. Nat Immunol. 2015; 16(8):819-828. PMC: 4512620. DOI: 10.1038/ni.3215. View

Kim B, Lee P, Lee S, Kim Y, Shin M, Kang Y . Long-Term Effects of Diesel Exhaust Particles on Airway Inflammation and Remodeling in a Mouse Model. Allergy Asthma Immunol Res. 2016; 8(3):246-56. PMC: 4773213. DOI: 10.4168/aair.2016.8.3.246. View

10.

Schorer M, Lambert K, Rakebrandt N, Rost F, Kao K, Yermanos A . Rapid expansion of Treg cells protects from collateral colitis following a viral trigger. Nat Commun. 2020; 11(1):1522. PMC: 7090079. DOI: 10.1038/s41467-020-15309-6. View

11.

Feldman S, Kasjanski R, Poposki J, Hernandez D, Chen J, Norton J . Chronic airway inflammation provides a unique environment for B cell activation and antibody production. Clin Exp Allergy. 2016; 47(4):457-466. PMC: 5378644. DOI: 10.1111/cea.12878. View

12.

Enoksson S, Grasset E, Hagglof T, Mattsson N, Kaiser Y, Gabrielsson S . The inflammatory cytokine IL-18 induces self-reactive innate antibody responses regulated by natural killer T cells. Proc Natl Acad Sci U S A. 2011; 108(51):E1399-407. PMC: 3251096. DOI: 10.1073/pnas.1107830108. View

13.

Mannucci P, Franchini M . Health Effects of Ambient Air Pollution in Developing Countries. Int J Environ Res Public Health. 2017; 14(9). PMC: 5615585. DOI: 10.3390/ijerph14091048. View

14.

Matsuo M, Shimada T, Uenishi R, Sasaki N, Sagai M . Diesel exhaust particle-induced cell death of cultured normal human bronchial epithelial cells. Biol Pharm Bull. 2003; 26(4):438-47. DOI: 10.1248/bpb.26.438. View

15.

Hiramatsu K, Azuma A, Kudoh S, Desaki M, Takizawa H, Sugawara I . Inhalation of diesel exhaust for three months affects major cytokine expression and induces bronchus-associated lymphoid tissue formation in murine lungs. Exp Lung Res. 2003; 29(8):607-22. DOI: 10.1080/01902140390240140. View

16.

Brauer M, Hoek G, Smit H, de Jongste J, Gerritsen J, Postma D . Air pollution and development of asthma, allergy and infections in a birth cohort. Eur Respir J. 2007; 29(5):879-88. DOI: 10.1183/09031936.00083406. View

17.

Southam D, Dolovich M, OByrne P, Inman M . Distribution of intranasal instillations in mice: effects of volume, time, body position, and anesthesia. Am J Physiol Lung Cell Mol Physiol. 2002; 282(4):L833-9. DOI: 10.1152/ajplung.00173.2001. View

18.

Strait R, Morris S, Yang M, Qu X, Finkelman F . Pathways of anaphylaxis in the mouse. J Allergy Clin Immunol. 2002; 109(4):658-68. DOI: 10.1067/mai.2002.123302. View

19.

Stevens W, Kim T, Pujanauski L, Hao X, Braciale T . Detection and quantitation of eosinophils in the murine respiratory tract by flow cytometry. J Immunol Methods. 2007; 327(1-2):63-74. PMC: 2670191. DOI: 10.1016/j.jim.2007.07.011. View

20.

Foo S, Phipps S . Regulation of inducible BALT formation and contribution to immunity and pathology. Mucosal Immunol. 2010; 3(6):537-44. DOI: 10.1038/mi.2010.52. View