The Central Nervous Mechanism of Stress-Promoting Cancer Progression

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2022 Oct 27

PMID 36293510

Authors

Yuchuan Hong

Lu Zhang

Nian Liu

Xirong Xu

Dan Liu

Jie Tu

Affiliations

Soon will be listed here.

Abstract

Evidence shows that stress can promote the occurrence and development of tumors. In recent years, many studies have shown that stress-related hormones or peripheral neurotransmitters can promote the proliferation, survival, and angiogenesis of tumor cells and impair the body's immune response, causing tumor cells to escape the "surveillance" of the immune system. However, the perception of stress occurs in the central nervous system (CNS) and the role of the central nervous system in tumor progression is still unclear, as are the underlying mechanisms. This review summarizes what is known of stress-related CNS-network activation during the stress response and the influence of the CNS on tumors and discusses available adjuvant treatment methods for cancer patients with negative emotional states, such as anxiety and depression.

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References

Armaiz-Pena G, Gonzalez-Villasana V, Nagaraja A, Rodriguez-Aguayo C, Sadaoui N, Stone R . Adrenergic regulation of monocyte chemotactic protein 1 leads to enhanced macrophage recruitment and ovarian carcinoma growth. Oncotarget. 2015; 6(6):4266-73. PMC: 4414188. DOI: 10.18632/oncotarget.2887. View

Ekstrand A, Cao R, Bjorndahl M, Nystrom S, Jonsson-Rylander A, Hassani H . Deletion of neuropeptide Y (NPY) 2 receptor in mice results in blockage of NPY-induced angiogenesis and delayed wound healing. Proc Natl Acad Sci U S A. 2003; 100(10):6033-8. PMC: 156321. DOI: 10.1073/pnas.1135965100. View

Bernabe D . Catecholamines Mediate Psychologic Stress-Induced Cancer Progression. Cancer Res. 2021; 81(20):5144-5146. DOI: 10.1158/0008-5472.CAN-21-3077. View

Heidt T, Sager H, Courties G, Dutta P, Iwamoto Y, Zaltsman A . Chronic variable stress activates hematopoietic stem cells. Nat Med. 2014; 20(7):754-758. PMC: 4087061. DOI: 10.1038/nm.3589. View

Kim-Fuchs C, Le C, Pimentel M, Shackleford D, Ferrari D, Angst E . Chronic stress accelerates pancreatic cancer growth and invasion: a critical role for beta-adrenergic signaling in the pancreatic microenvironment. Brain Behav Immun. 2014; 40:40-7. PMC: 4102665. DOI: 10.1016/j.bbi.2014.02.019. View

Magnon C, Hall S, Lin J, Xue X, Gerber L, Freedland S . Autonomic nerve development contributes to prostate cancer progression. Science. 2013; 341(6142):1236361. DOI: 10.1126/science.1236361. View

Won E, Kim Y . Stress, the Autonomic Nervous System, and the Immune-kynurenine Pathway in the Etiology of Depression. Curr Neuropharmacol. 2016; 14(7):665-73. PMC: 5050399. DOI: 10.2174/1570159x14666151208113006. View

Saha S . Role of the central nucleus of the amygdala in the control of blood pressure: descending pathways to medullary cardiovascular nuclei. Clin Exp Pharmacol Physiol. 2005; 32(5-6):450-6. DOI: 10.1111/j.1440-1681.2005.04210.x. View

Harman D . Aging: a theory based on free radical and radiation chemistry. J Gerontol. 1956; 11(3):298-300. DOI: 10.1093/geronj/11.3.298. View

10.

Muscatell K, Eisenberger N, Dutcher J, Cole S, Bower J . Links between inflammation, amygdala reactivity, and social support in breast cancer survivors. Brain Behav Immun. 2015; 53:34-38. PMC: 5784760. DOI: 10.1016/j.bbi.2015.09.008. View

11.

Herman J, Figueiredo H, Mueller N, Ulrich-Lai Y, Ostrander M, Choi D . Central mechanisms of stress integration: hierarchical circuitry controlling hypothalamo-pituitary-adrenocortical responsiveness. Front Neuroendocrinol. 2003; 24(3):151-80. DOI: 10.1016/j.yfrne.2003.07.001. View

12.

Reeder A, Attar M, Nazario L, Bathula C, Zhang A, Hochbaum D . Stress hormones reduce the efficacy of paclitaxel in triple negative breast cancer through induction of DNA damage. Br J Cancer. 2015; 112(9):1461-70. PMC: 4453678. DOI: 10.1038/bjc.2015.133. View

13.

Hu Z, Mu Y, Huang L, Hu Y, Chen Z, Yang Y . A visual circuit related to the periaqueductal gray area for the antinociceptive effects of bright light treatment. Neuron. 2022; 110(10):1712-1727.e7. DOI: 10.1016/j.neuron.2022.02.009. View

14.

Borniger J, Walker Ii W, Surbhi , Emmer K, Zhang N, Zalenski A . A Role for Hypocretin/Orexin in Metabolic and Sleep Abnormalities in a Mouse Model of Non-metastatic Breast Cancer. Cell Metab. 2018; 28(1):118-129.e5. PMC: 6031468. DOI: 10.1016/j.cmet.2018.04.021. View

15.

Ray A, Gulati K, Rai N . Stress, Anxiety, and Immunomodulation: A Pharmacological Analysis. Vitam Horm. 2017; 103:1-25. DOI: 10.1016/bs.vh.2016.09.007. View

16.

Herman J, Cullinan W, Ziegler D, Tasker J . Role of the paraventricular nucleus microenvironment in stress integration. Eur J Neurosci. 2002; 16(3):381-5. DOI: 10.1046/j.1460-9568.2002.02133.x. View

17.

Lu C, Everhart L, Tilan J, Kuo L, Sun C, Munivenkatappa R . Neuropeptide Y and its Y2 receptor: potential targets in neuroblastoma therapy. Oncogene. 2010; 29(41):5630-42. PMC: 2955165. DOI: 10.1038/onc.2010.301. View

18.

Huang L, Xi Y, Peng Y, Yang Y, Huang X, Fu Y . A Visual Circuit Related to Habenula Underlies the Antidepressive Effects of Light Therapy. Neuron. 2019; 102(1):128-142.e8. DOI: 10.1016/j.neuron.2019.01.037. View

19.

Onorati A, Havas A, Lin B, Rajagopal J, Sen P, Adams P . Upregulation of PD-L1 in Senescence and Aging. Mol Cell Biol. 2022; 42(10):e0017122. PMC: 9583718. DOI: 10.1128/mcb.00171-22. View

20.

Brechner T, Motyka D, Sherman J . Growth enhancement of prolactin-sensitive mammary tumor by periaqueductal gray stimulation. Life Sci. 1983; 32(5):525-30. DOI: 10.1016/0024-3205(83)90147-9. View