Molecular Mechanisms of Diverse Auxin Responses During Plant Growth and Development

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2022 Oct 27

PMID 36293351

Authors

Yang Zhang

Jiajie Yu

Xiuyue Xu

Ruiqi Wang

Yingying Liu

Shan Huang

Hairong Wei

Zhigang Wei

Affiliations

Soon will be listed here.

Abstract

The plant hormone auxin acts as a signaling molecule to regulate numerous developmental processes throughout all stages of plant growth. Understanding how auxin regulates various physiological and developmental processes has been a hot topic and an intriguing field. Recent studies have unveiled more molecular details into how diverse auxin responses function in every aspect of plant growth and development. In this review, we systematically summarized and classified the molecular mechanisms of diverse auxin responses, and comprehensively elaborated the characteristics and multilevel regulation mechanisms of the canonical transcriptional auxin response. On this basis, we described the characteristics and differences between different auxin responses. We also presented some auxin response genes that have been genetically modified in plant species and how their changes impact various traits of interest. Finally, we summarized some important aspects and unsolved questions of auxin responses that need to be focused on or addressed in future research. This review will help to gain an overall understanding of and some insights into the diverse molecular mechanisms of auxin responses in plant growth and development that are instrumental in harnessing genetic resources in molecular breeding of extant plant species.

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References

Strader L, Monroe-Augustus M, Bartel B . The IBR5 phosphatase promotes Arabidopsis auxin responses through a novel mechanism distinct from TIR1-mediated repressor degradation. BMC Plant Biol. 2008; 8:41. PMC: 2374786. DOI: 10.1186/1471-2229-8-41. View

Li W, Dang C, Ye Y, Wang Z, Hu B, Zhang F . Overexpression of Grapevine Gene Enhanced Salt Tolerance in Tobacco. Int J Mol Sci. 2020; 21(4). PMC: 7072961. DOI: 10.3390/ijms21041323. View

McCue K, Gardner E, Chan R, Thilmony R, Thomson J . Transgene stacking in potato using the GAANTRY system. BMC Res Notes. 2019; 12(1):457. PMC: 6659271. DOI: 10.1186/s13104-019-4493-8. View

Schlereth A, Moller B, Liu W, Kientz M, Flipse J, Rademacher E . MONOPTEROS controls embryonic root initiation by regulating a mobile transcription factor. Nature. 2010; 464(7290):913-6. DOI: 10.1038/nature08836. View

Rademacher E, Moller B, Lokerse A, Llavata-Peris C, van den Berg W, Weijers D . A cellular expression map of the Arabidopsis AUXIN RESPONSE FACTOR gene family. Plant J. 2011; 68(4):597-606. DOI: 10.1111/j.1365-313X.2011.04710.x. View

Shin R, Burch A, Huppert K, Tiwari S, Murphy A, Guilfoyle T . The Arabidopsis transcription factor MYB77 modulates auxin signal transduction. Plant Cell. 2007; 19(8):2440-53. PMC: 2002618. DOI: 10.1105/tpc.107.050963. View

Zemlyanskaya E, Wiebe D, Omelyanchuk N, Levitsky V, Mironova V . Meta-analysis of transcriptome data identified TGTCNN motif variants associated with the response to plant hormone auxin in Arabidopsis thaliana L. J Bioinform Comput Biol. 2016; 14(2):1641009. DOI: 10.1142/S0219720016410092. View

Wu G, Lin W, Huang T, Poethig R, Springer P, Kerstetter R . KANADI1 regulates adaxial-abaxial polarity in Arabidopsis by directly repressing the transcription of ASYMMETRIC LEAVES2. Proc Natl Acad Sci U S A. 2008; 105(42):16392-7. PMC: 2571004. DOI: 10.1073/pnas.0803997105. View

Simonini S, Bencivenga S, Trick M, Ostergaard L . Auxin-Induced Modulation of ETTIN Activity Orchestrates Gene Expression in Arabidopsis. Plant Cell. 2017; 29(8):1864-1882. PMC: 5590509. DOI: 10.1105/tpc.17.00389. View

10.

Saiga S, Moller B, Watanabe-Taneda A, Abe M, Weijers D, Komeda Y . Control of embryonic meristem initiation in Arabidopsis by PHD-finger protein complexes. Development. 2012; 139(8):1391-8. DOI: 10.1242/dev.074492. View

11.

Okushima Y, Fukaki H, Onoda M, Theologis A, Tasaka M . ARF7 and ARF19 regulate lateral root formation via direct activation of LBD/ASL genes in Arabidopsis. Plant Cell. 2007; 19(1):118-30. PMC: 1820965. DOI: 10.1105/tpc.106.047761. View

12.

Huang D, Wang Q, Duan D, Dong Q, Zhao S, Zhang M . Overexpression of confers high tolerance to osmotic stress in transgenic tobacco. PeerJ. 2019; 7:e7935. PMC: 6825743. DOI: 10.7717/peerj.7935. View

13.

Zhang X, Fu X, Liu F, Wang Y, Bi H, Ai X . Hydrogen Sulfide Improves the Cold Stress Resistance through the CsARF5-CsDREB3 Module in Cucumber. Int J Mol Sci. 2021; 22(24). PMC: 8706816. DOI: 10.3390/ijms222413229. View

14.

Guilfoyle T, Hagen G . Auxin response factors. Curr Opin Plant Biol. 2007; 10(5):453-60. DOI: 10.1016/j.pbi.2007.08.014. View

15.

Fu Y, Gu Y, Zheng Z, Wasteneys G, Yang Z . Arabidopsis interdigitating cell growth requires two antagonistic pathways with opposing action on cell morphogenesis. Cell. 2005; 120(5):687-700. DOI: 10.1016/j.cell.2004.12.026. View

16.

Pierre-Jerome E, Moss B, Nemhauser J . Tuning the auxin transcriptional response. J Exp Bot. 2013; 64(9):2557-63. DOI: 10.1093/jxb/ert100. View

17.

Xu J, Li J, Cui L, Zhang T, Wu Z, Zhu P . New insights into the roles of cucumber TIR1 homologs and miR393 in regulating fruit/seed set development and leaf morphogenesis. BMC Plant Biol. 2017; 17(1):130. PMC: 5530481. DOI: 10.1186/s12870-017-1075-6. View

18.

Li S, Xie Z, Hu C, Zhang J . A Review of Auxin Response Factors (ARFs) in Plants. Front Plant Sci. 2016; 7:47. PMC: 4737911. DOI: 10.3389/fpls.2016.00047. View

19.

Boer D, Freire-Rios A, van den Berg W, Saaki T, Manfield I, Kepinski S . Structural basis for DNA binding specificity by the auxin-dependent ARF transcription factors. Cell. 2014; 156(3):577-89. DOI: 10.1016/j.cell.2013.12.027. View

20.

Zhang L, Cai X, Wu J, Liu M, Grob S, Cheng F . Improved reference genome by single-molecule sequencing and chromosome conformation capture technologies. Hortic Res. 2018; 5:50. PMC: 6092429. DOI: 10.1038/s41438-018-0071-9. View