Tissue Engineering in Gynecology

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2022 Oct 27

PMID 36293171

Authors

David Brownell

Stephane Chabaud

Stephane Bolduc

Affiliations

Soon will be listed here.

Abstract

Female gynecological organ dysfunction can cause infertility and psychological distress, decreasing the quality of life of affected women. Incidence is constantly increasing due to growing rates of cancer and increase of childbearing age in the developed world. Current treatments are often unable to restore organ function, and occasionally are the cause of female infertility. Alternative treatment options are currently being developed in order to face the inadequacy of current practices. In this review, pathologies and current treatments of gynecological organs (ovaries, uterus, and vagina) are described. State-of-the-art of tissue engineering alternatives to common practices are evaluated with a focus on in vivo models. Tissue engineering is an ever-expanding field, integrating various domains of modern science to create sophisticated tissue substitutes in the hope of repairing or replacing dysfunctional organs using autologous cells. Its application to gynecology has the potential of restoring female fertility and sexual wellbeing.

Citing Articles

Impact of Endocrine Disruptors on the Genitourinary Tract.

Caneparo C, Carignan L, Lonina E, Goulet S, Pellerin F, Chabaud S J Xenobiot. 2024; 14(4):1849-1888.

PMID: 39728407 PMC: 11676856. DOI: 10.3390/jox14040099.

Exploring the innovative application of cerium oxide nanoparticles for addressing oxidative stress in ovarian tissue regeneration.

Lakshmanan M, Saini M, Nune M J Ovarian Res. 2024; 17(1):241.

PMID: 39633503 PMC: 11619646. DOI: 10.1186/s13048-024-01566-2.

Biomimicking trilayer scaffolds with controlled estradiol release for uterine tissue regeneration.

Chen S, Li J, Zheng L, Huang J, Wang M Exploration (Beijing). 2024; 4(5):20230141.

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Evaluation of Bi-layer Silk Fibroin Grafts for Inlay Vaginoplasty in a Rat Model.

Nguyen T, Gundogdu G, Bottini C, Chaudhuri A, Mauney J Tissue Eng Regen Med. 2024; 21(7):985-994.

PMID: 38822221 PMC: 11416452. DOI: 10.1007/s13770-024-00653-1.

Extracellular Matrix-Based and Electrospun Scaffolding Systems for Vaginal Reconstruction.

Farzamfar S, Elia E, Richer M, Chabaud S, Naji M, Bolduc S Bioengineering (Basel). 2023; 10(7).

PMID: 37508817 PMC: 10376078. DOI: 10.3390/bioengineering10070790.

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