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Meta-Analysis Reveals Challenges and Gaps for Genome-to-Phenome Research Underpinning Plant Drought Response

Overview
Journal Int J Mol Sci
Publisher MDPI
Date 2022 Oct 27
PMID 36293161
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Abstract

Severe drought conditions and extreme weather events are increasing worldwide with climate change, threatening the persistence of native plant communities and ecosystems. Many studies have investigated the genomic basis of plant responses to drought. However, the extent of this research throughout the plant kingdom is unclear, particularly among species critical for the sustainability of natural ecosystems. This study aimed to broaden our understanding of genome-to-phenome (G2P) connections in drought-stressed plants and identify focal taxa for future research. Bioinformatics pipelines were developed to mine and link information from databases and abstracts from 7730 publications. This approach identified 1634 genes involved in drought responses among 497 plant taxa. Most (83.30%) of these species have been classified for human use, and most G2P interactions have been described within model organisms or crop species. Our analysis identifies several gaps in G2P research literature and database connectivity, with 21% of abstracts being linked to gene and taxonomy data in NCBI. Abstract text mining was more successful at identifying potential G2P pathways, with 34% of abstracts containing gene, taxa, and phenotype information. Expanding G2P studies to include non-model plants, especially those that are adapted to drought stress, will help advance our understanding of drought responsive G2P pathways.

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References
1.
Akbudak M, Filiz E, Uylas S . Identification of O-acetylserine(thiol)lyase (OASTL) genes in sorghum (Sorghum bicolor) and gene expression analysis under cadmium stress. Mol Biol Rep. 2018; 46(1):343-354. DOI: 10.1007/s11033-018-4477-0. View

2.
Melton A, Beck J, Galla S, Jenkins J, Handley L, Kim M . A draft genome provides hypotheses on drought tolerance in a keystone plant species in Western North America threatened by climate change. Ecol Evol. 2021; 11(21):15417-15429. PMC: 8571618. DOI: 10.1002/ece3.8245. View

3.
Urban M, Zarnetske P, Skelly D . Moving forward: dispersal and species interactions determine biotic responses to climate change. Ann N Y Acad Sci. 2013; 1297:44-60. DOI: 10.1111/nyas.12184. View

4.
Gutzat R, Mittelsten Scheid O . Epigenetic responses to stress: triple defense?. Curr Opin Plant Biol. 2012; 15(5):568-73. PMC: 3508409. DOI: 10.1016/j.pbi.2012.08.007. View

5.
Joshi R, Wani S, Singh B, Bohra A, Dar Z, Lone A . Transcription Factors and Plants Response to Drought Stress: Current Understanding and Future Directions. Front Plant Sci. 2016; 7:1029. PMC: 4943945. DOI: 10.3389/fpls.2016.01029. View