The Association Between the Rs671 Polymorphism and Athletic Performance in Japanese Power and Strength Athletes

Overview

Journal Genes (Basel)

Publisher MDPI

Date 2022 Oct 27

PMID 36292620

Authors

Aoto Saito

Mika Saito

Kathleen Y de Almeida

Hiroki Homma

Minoru Deguchi

Ayumu Kozuma

Naoyuki Kobatake

Takanobu Okamoto

Koichi Nakazato

Naoki Kikuchi

Affiliations

Soon will be listed here.

Abstract

The rs671 polymorphism is associated with the enzymatic activity of aldehyde dehydrogenase 2 (ALDH2), which is weakened by the A allele in East Asians. We recently reported the association of this polymorphism with the athletic status in athletic cohorts and the muscle strength of non-athletic cohorts. Therefore, we hypothesized the association of rs671 polymorphism with the performance in power/strength athletes. We aimed to clarify the relationship between the rs671 polymorphism and performance in power/strength athletes. Participants comprising 253 power/strength athletes (167 men and 86 women) and 721 healthy controls (303 men and 418 women) were investigated. The power/strength athletes were divided into classic powerlifting ( = 84) and weightlifting ( = 169). No differences in the genotypes and allele frequencies of the rs671 polymorphism and an association between performance and the rs671 genotype were observed in weightlifters. However, the relative values per body weight of the total record were lower in powerlifters with the GA + AA genotype than those with the GG genotype (7.1 ± 1.2 vs. 7.8 ± 1.0; = 0.010, partial η = 0.08). Our results collectively indicate a role of the rs671 polymorphism in strength performance in powerlifters.

Citing Articles

The () Genetic Variant Is Associated with Muscle Fiber Size and Strength Athlete Status.

Cigirtas R, Bulgay C, Kazan H, Akman O, Sporis G, John G Metabolites. 2024; 14(12).

PMID: 39728465 PMC: 11676174. DOI: 10.3390/metabo14120684.

Dopamine in Sports: A Narrative Review on the Genetic and Epigenetic Factors Shaping Personality and Athletic Performance.

Huminska-Lisowska K Int J Mol Sci. 2024; 25(21).

PMID: 39519153 PMC: 11546834. DOI: 10.3390/ijms252111602.

Influence of genetic polymorphism on sports talent performance versus non-athletes: a systematic review and meta-analysis.

Ferreira C, Silvino V, Trevisano R, de Moura R, Almeida S, Dos Santos M BMC Sports Sci Med Rehabil. 2024; 16(1):223.

PMID: 39482721 PMC: 11529235. DOI: 10.1186/s13102-024-01001-5.

Genes and Athletic Performance: The 2023 Update.

Semenova E, Hall E, Ahmetov I Genes (Basel). 2023; 14(6).

PMID: 37372415 PMC: 10298527. DOI: 10.3390/genes14061235.

References

Xiao Q, Weiner H, Crabb D . The mutation in the mitochondrial aldehyde dehydrogenase (ALDH2) gene responsible for alcohol-induced flushing increases turnover of the enzyme tetramers in a dominant fashion. J Clin Invest. 1996; 98(9):2027-32. PMC: 507646. DOI: 10.1172/JCI119007. View

Liu J, Chang W, Chan K, Tsai W, Lin C, Hsu M . Blood lipid peroxides and muscle damage increased following intensive resistance training of female weightlifters. Ann N Y Acad Sci. 2005; 1042:255-61. DOI: 10.1196/annals.1338.029. View

Wakabayashi Y, Tamura Y, Kouzaki K, Kikuchi N, Hiranuma K, Menuki K . Acetaldehyde dehydrogenase 2 deficiency increases mitochondrial reactive oxygen species emission and induces mitochondrial protease Omi/HtrA2 in skeletal muscle. Am J Physiol Regul Integr Comp Physiol. 2020; 318(4):R677-R690. DOI: 10.1152/ajpregu.00089.2019. View

Kobayashi H, Nakamura S, Sato Y, Kobayashi T, Miyamoto K, Oya A . ALDH2 mutation promotes skeletal muscle atrophy in mice via accumulation of oxidative stress. Bone. 2020; 142:115739. DOI: 10.1016/j.bone.2020.115739. View

Wen W, Zheng W, Okada Y, Takeuchi F, Tabara Y, Hwang J . Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index. Hum Mol Genet. 2014; 23(20):5492-504. PMC: 4168820. DOI: 10.1093/hmg/ddu248. View

Fry A, Webber J, Weiss L, Harber M, Vaczi M, Pattison N . Muscle fiber characteristics of competitive power lifters. J Strength Cond Res. 2003; 17(2):402-10. DOI: 10.1519/1533-4287(2003)017<0402:mfcocp>2.0.co;2. View

Kregel K, Zhang H . An integrated view of oxidative stress in aging: basic mechanisms, functional effects, and pathological considerations. Am J Physiol Regul Integr Comp Physiol. 2006; 292(1):R18-36. DOI: 10.1152/ajpregu.00327.2006. View

Kikuchi N, Tajima T, Tamura Y, Yamanaka Y, Menuki K, Okamoto T . The rs671 polymorphism is associated with athletic status and muscle strength in a Japanese population. Biol Sport. 2022; 39(2):429-434. PMC: 8919894. DOI: 10.5114/biolsport.2022.106151. View

Folland J, Williams A . The adaptations to strength training : morphological and neurological contributions to increased strength. Sports Med. 2007; 37(2):145-68. DOI: 10.2165/00007256-200737020-00004. View

10.

Fry A, Schilling B, Staron R, Hagerman F, Hikida R, Thrush J . Muscle fiber characteristics and performance correlates of male Olympic-style weightlifters. J Strength Cond Res. 2003; 17(4):746-54. DOI: 10.1519/1533-4287(2003)017<0746:mfcapc>2.0.co;2. View

11.

Wu Y, Ni J, Cai X, Lian F, Ma H, Xu L . Positive association between ALDH2 rs671 polymorphism and essential hypertension: A case-control study and meta-analysis. PLoS One. 2017; 12(5):e0177023. PMC: 5417637. DOI: 10.1371/journal.pone.0177023. View

12.

Zuo W, Zhan Z, Ma L, Bai W, Zeng S . Effect of ALDH2 polymorphism on cancer risk in Asians: A meta-analysis. Medicine (Baltimore). 2019; 98(13):e14855. PMC: 6456109. DOI: 10.1097/MD.0000000000014855. View

13.

Ahmetov I, Naumov V, Donnikov A, Maciejewska-Karlowska A, Kostryukova E, Larin A . SOD2 gene polymorphism and muscle damage markers in elite athletes. Free Radic Res. 2014; 48(8):948-55. DOI: 10.3109/10715762.2014.928410. View

14.

Caceres-Ayala C, Pautassi R, Acuna M, Cerpa W, Rebolledo D . The functional and molecular effects of problematic alcohol consumption on skeletal muscle: a focus on athletic performance. Am J Drug Alcohol Abuse. 2022; 48(2):133-147. DOI: 10.1080/00952990.2022.2041025. View

15.

Stepto N, Coffey V, Carey A, Ponnampalam A, Canny B, Powell D . Global gene expression in skeletal muscle from well-trained strength and endurance athletes. Med Sci Sports Exerc. 2009; 41(3):546-65. DOI: 10.1249/MSS.0b013e31818c6be9. View

16.

Romanello V, Sandri M . Mitochondrial Quality Control and Muscle Mass Maintenance. Front Physiol. 2016; 6:422. PMC: 4709858. DOI: 10.3389/fphys.2015.00422. View

17.

Chung H, Keiller D, Roberts J, Gordon D . Do exercise-associated genes explain phenotypic variance in the three components of fitness? a systematic review & meta-analysis. PLoS One. 2021; 16(10):e0249501. PMC: 8516263. DOI: 10.1371/journal.pone.0249501. View

18.

Jurgenson J, Serg M, Kampus P, Kals J, Zagura M, Viru M . Oxidative Stress Parameters and Its Associations With Arterial Stiffness in Competitive Powerlifting Athletes After 12-Week Supervised Strength Training. J Strength Cond Res. 2019; 33(7):1816-1822. DOI: 10.1519/JSC.0000000000003067. View

19.

Lin C, Chien R, Chen L, Huang T, Shyu Y, Yeh C . The Aldehyde Dehydrogenase ALDH2*2 Allele, Associated with Alcohol Drinking Behavior, Dates Back to Prehistoric Times. Biomolecules. 2021; 11(9). PMC: 8465343. DOI: 10.3390/biom11091376. View

20.

Storey A, Smith H . Unique aspects of competitive weightlifting: performance, training and physiology. Sports Med. 2012; 42(9):769-90. DOI: 10.1007/BF03262294. View