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The Association Between the Rs671 Polymorphism and Athletic Performance in Japanese Power and Strength Athletes

Overview
Journal Genes (Basel)
Publisher MDPI
Date 2022 Oct 27
PMID 36292620
Authors
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Abstract

The rs671 polymorphism is associated with the enzymatic activity of aldehyde dehydrogenase 2 (ALDH2), which is weakened by the A allele in East Asians. We recently reported the association of this polymorphism with the athletic status in athletic cohorts and the muscle strength of non-athletic cohorts. Therefore, we hypothesized the association of rs671 polymorphism with the performance in power/strength athletes. We aimed to clarify the relationship between the rs671 polymorphism and performance in power/strength athletes. Participants comprising 253 power/strength athletes (167 men and 86 women) and 721 healthy controls (303 men and 418 women) were investigated. The power/strength athletes were divided into classic powerlifting ( = 84) and weightlifting ( = 169). No differences in the genotypes and allele frequencies of the rs671 polymorphism and an association between performance and the rs671 genotype were observed in weightlifters. However, the relative values per body weight of the total record were lower in powerlifters with the GA + AA genotype than those with the GG genotype (7.1 ± 1.2 vs. 7.8 ± 1.0; = 0.010, partial η = 0.08). Our results collectively indicate a role of the rs671 polymorphism in strength performance in powerlifters.

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