Hypovitaminosis D and Metabolic Syndrome in Postmenopausal Women

Overview

Journal Healthcare (Basel)

Specialty Health Services

Date 2022 Oct 27

PMID 36292473

Authors

Haya Abuhijleh

Dana Alkhatib

Vijay Ganji

Affiliations

Soon will be listed here.

Abstract

Metabolic syndrome (MetSyn) is a precursor for several cardiometabolic diseases. The prevalence of MetSyn is higher in postmenopausal women compared to premenopausal women. The role of vitamin D in postmenopausal women is not clearly understood. Hypovitaminosis D is more prevalent in postmenopausal women compared to premenopausal women. For this review, Pubmed, Cochrane, SCOPUS, Embase, and Google Scholar databases were searched up to August 2022. Findings from one randomized controlled trial (RCT) and ten cross-sectional studies were included in this review. Several cross-sectional studies (8 out of 10 reviewed) unequivocally demonstrated an inverse association between serum 25-hydroxyvitamin D concentrations and MetSyn. However, RCTs are severely lacking in the effect of vitamin D intake on the biomarkers of MetSyn and the prevalence of MetSyn. Therefore, caution should be used in recommending mega doses of vitamin D supplements for postmenopausal women because of the potential adverse effects associated with this vitamer.

Citing Articles

Relationship between Circulating 25-Hydroxyvitamin D and Metabolic Syndrome in Chinese Adults: A Large Nationwide Longitudinal Study.

Shu M, Xi Y, Wu J, Zhuo L, Yan Y, Yang Y Nutrients. 2024; 16(10).

PMID: 38794718 PMC: 11124364. DOI: 10.3390/nu16101480.

Population-Level Nutritional Well-Being: Nutrition Security and Equitability.

Reid K Healthcare (Basel). 2023; 11(6).

PMID: 36981474 PMC: 10048516. DOI: 10.3390/healthcare11060817.

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