» Articles » PMID: 36292285

Obesity As a Risk Factor for Severe COVID-19 in Hospitalized Patients: Epidemiology and Potential Mechanisms

Overview
Specialty Health Services
Date 2022 Oct 27
PMID 36292285
Authors
Affiliations
Soon will be listed here.
Abstract

SARS-CoV-2 infection is a global public health problem, causing significant morbidity and mortality. Evidence shows that obesity is a recognized risk factor for hospitalization, admission to critical care units, and the development of serious complications from COVID-19. This review analyzes the available epidemiological evidence that relates obesity to a higher risk of severity and mortality from COVID-19, examining the possible pathophysiological mechanisms that explain this phenomenon on a cellular and molecular level.

Citing Articles

Impact of Obesity-Associated SARS-CoV-2 Mutations on COVID-19 Severity and Clinical Outcomes.

Martinez-Martinez A, Tristancho-Baro A, Garcia-Rodriguez B, Clavel-Millan M, Palacian M, Milagro A Viruses. 2025; 17(1).

PMID: 39861827 PMC: 11769164. DOI: 10.3390/v17010038.


Serological survey in a university community after the fourth wave of COVID-19 in Senegal.

Thiam F, Diouara A, Ndiaye C, Diouf I, Kebe K, Senghor A PLoS One. 2024; 19(11):e0298509.

PMID: 39570844 PMC: 11581233. DOI: 10.1371/journal.pone.0298509.


Identifying Mortality Predictors in Hospitalized COVID-19 Patients: Insights from a Single-Center Retrospective Study at a University Hospital.

Zahornacky O, Rovnakova A, Surimova M, Porubcin S, Jarcuska P Microorganisms. 2024; 12(5).

PMID: 38792861 PMC: 11124314. DOI: 10.3390/microorganisms12051032.


Exploring the intersection of obesity and gender in COVID-19 outcomes in hospitalized Mexican patients: a comparative analysis of risk profiles using unsupervised machine learning.

Nezhadmoghadam F, Tamez-Pena J, Martinez-Ledesma E Front Public Health. 2024; 12:1337432.

PMID: 38699419 PMC: 11063238. DOI: 10.3389/fpubh.2024.1337432.


NASAFYTOL supplementation in adults hospitalized with COVID-19 infection: results from an exploratory open-label randomized controlled trial.

Gerain J, Uebelhoer M, Costes B, Herman J, Pietri S, Donneau A Front Nutr. 2023; 10:1137407.

PMID: 37426178 PMC: 10324407. DOI: 10.3389/fnut.2023.1137407.


References
1.
E Silva J, Pereira Vasconcelos A, Noma I, Noronha N, Aquino R, Giddaluru J . Gene signatures of autopsy lungs from obese patients with COVID-19. Clin Nutr ESPEN. 2021; 44:475-478. PMC: 8149170. DOI: 10.1016/j.clnesp.2021.05.004. View

2.
Pettit N, MacKenzie E, Ridgway J, Pursell K, Ash D, Patel B . Obesity is Associated with Increased Risk for Mortality Among Hospitalized Patients with COVID-19. Obesity (Silver Spring). 2020; 28(10):1806-1810. PMC: 7362135. DOI: 10.1002/oby.22941. View

3.
Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J . Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China. JAMA. 2020; 323(11):1061-1069. PMC: 7042881. DOI: 10.1001/jama.2020.1585. View

4.
Chu Y, Yang J, Shi J, Zhang P, Wang X . Obesity is associated with increased severity of disease in COVID-19 pneumonia: a systematic review and meta-analysis. Eur J Med Res. 2020; 25(1):64. PMC: 7708895. DOI: 10.1186/s40001-020-00464-9. View

5.
Stefan N, Birkenfeld A, Schulze M . Global pandemics interconnected - obesity, impaired metabolic health and COVID-19. Nat Rev Endocrinol. 2021; 17(3):135-149. DOI: 10.1038/s41574-020-00462-1. View