Cancer-Derived Extracellular Vesicles As Biomarkers for Cutaneous Squamous Cell Carcinoma: A Systematic Review

Overview

Journal Cancers (Basel)

Publisher MDPI

Specialty Oncology

Date 2022 Oct 27

PMID 36291882

Authors

Irene Tai-Lin Lee

Chin-Hsuan Shen

Feng-Chiao Tsai

Chun-Bing Chen

Kevin Sheng-Kai Ma

Affiliations

Soon will be listed here.

Abstract

Cutaneous squamous cell carcinoma (cSCC) as one of the most prevalent cancers worldwide is associated with significant morbidity and mortality. Full-body skin exam and biopsy is the gold standard for cSCC diagnosis, but it is not always feasible given constraints on time and costs. Furthermore, biopsy fails to reflect the dynamic changes in tumor genomes, which challenges long-term medical treatment in patients with advanced diseases. Extracellular vesicle (EV) is an emerging biological entity in oncology with versatile clinical applications from screening to treatment. In this systematic review, pre-clinical and clinical studies on cSCC-derived EVs were summarized. Seven studies on the genomics, transcriptomics, and proteomics of cSCC-derived EVs were identified. The contents in cSCC-derived EVs may reflect the mutational landscape of the original cancer cells or be selectively enriched in EVs. Desmoglein 2 protein (Dsg2) is an important molecule in the biogenesis of cSCC-derived EVs. Ct-SLCO1B3 mRNA, and CYP24A1 circular RNA (circRNA) are enriched in cSCC-derived EVs, suggesting potentials in cSCC screening and diagnosis. p38 inhibited cSCC-associated long intergenic non-coding RNA (linc-PICSAR) and Dsg2 involved in EV-mediated tumor invasion and drug resistance served as prognostic and therapeutic predictors. We also proposed future directions to devise EV-based cSCC treatment based on these molecules and preliminary studies in other cancers.

Citing Articles

Micro RNA Dysregulation in Keratinocyte Carcinomas: Clinical Evidence, Functional Impact, and Future Directions.

Conley J, Genenger B, Ashford B, Ranson M Int J Mol Sci. 2024; 25(15).

PMID: 39126067 PMC: 11313315. DOI: 10.3390/ijms25158493.

Extracellular Vesicles as Novel Diagnostic and Therapeutic Agents for Non-Melanoma Skin Cancer: A Systematic Review.

Seretis K, Boptsi E, Boptsi A Int J Mol Sci. 2024; 25(5).

PMID: 38473864 PMC: 10931606. DOI: 10.3390/ijms25052617.

Unveiling the mechanisms and challenges of cancer drug resistance.

Khan S, Fatima K, Aisha S, Malik F Cell Commun Signal. 2024; 22(1):109.

PMID: 38347575 PMC: 10860306. DOI: 10.1186/s12964-023-01302-1.

Desmoglein-2 as a cancer modulator: friend or foe?.

Myo Min K, Ffrench C, McClure B, Ortiz M, Dorward E, Samuel M Front Oncol. 2024; 13:1327478.

PMID: 38188287 PMC: 10766750. DOI: 10.3389/fonc.2023.1327478.

Ocular surface complications following biological therapy for cancer.

Ma K, Tsai P, Hsieh T, Chodosh J Front Toxicol. 2023; 5:1137637.

PMID: 37424746 PMC: 10324604. DOI: 10.3389/ftox.2023.1137637.

References

Fukuda S, Akiyama M, Niki Y, Kawatsura R, Harada H, Nakahama K . Inhibitory effects of miRNAs in astrocytes on C6 glioma progression via connexin 43. Mol Cell Biochem. 2021; 476(7):2623-2632. DOI: 10.1007/s11010-021-04118-0. View

McGranahan N, Swanton C . Clonal Heterogeneity and Tumor Evolution: Past, Present, and the Future. Cell. 2017; 168(4):613-628. DOI: 10.1016/j.cell.2017.01.018. View

Jia E, Ren N, Shi X, Zhang R, Yu H, Yu F . Extracellular vesicle biomarkers for pancreatic cancer diagnosis: a systematic review and meta-analysis. BMC Cancer. 2022; 22(1):573. PMC: 9125932. DOI: 10.1186/s12885-022-09463-x. View

Li S, Wu Y, Ding F, Yang J, Li J, Gao X . Engineering macrophage-derived exosomes for targeted chemotherapy of triple-negative breast cancer. Nanoscale. 2020; 12(19):10854-10862. DOI: 10.1039/d0nr00523a. View

Wang D, Zhou X, Yin J, Zhou Y . Lnc-PICSAR contributes to cisplatin resistance by miR-485-5p/REV3L axis in cutaneous squamous cell carcinoma. Open Life Sci. 2021; 15(1):488-500. PMC: 7874590. DOI: 10.1515/biol-2020-0049. View

Overmiller A, Pierluissi J, Wermuth P, Sauma S, Martinez-Outschoorn U, Tuluc M . Desmoglein 2 modulates extracellular vesicle release from squamous cell carcinoma keratinocytes. FASEB J. 2017; 31(8):3412-3424. PMC: 5503718. DOI: 10.1096/fj.201601138RR. View

Chiang C, Chiang C, Peng C, Hsia Y, See X, Horng C . Efficacy of cationic amphiphilic antihistamines on outcomes of patients treated with immune checkpoint inhibitors. Eur J Cancer. 2022; 174:1-9. DOI: 10.1016/j.ejca.2022.07.006. View

Serrati S, Guida M, Di Fonte R, De Summa S, Strippoli S, Iacobazzi R . Circulating extracellular vesicles expressing PD1 and PD-L1 predict response and mediate resistance to checkpoint inhibitors immunotherapy in metastatic melanoma. Mol Cancer. 2022; 21(1):20. PMC: 8764806. DOI: 10.1186/s12943-021-01490-9. View

Guo J, Wang S, Jiang Z, Tang L, Liu Z, Cao J . Long Non-Coding RNA RFPL3S Functions as a Biomarker of Prognostic and Immunotherapeutic Prediction in Testicular Germ Cell Tumor. Front Immunol. 2022; 13:859730. PMC: 9165694. DOI: 10.3389/fimmu.2022.859730. View

10.

Wang S . Extracellular vesicles in cancer therapy. Semin Cancer Biol. 2022; 86(Pt 2):296-309. PMC: 10431950. DOI: 10.1016/j.semcancer.2022.06.001. View

11.

Roozeboom M, Lohman B, Westers-Attema A, Nelemans P, Botterweck A, van Marion A . Clinical and histological prognostic factors for local recurrence and metastasis of cutaneous squamous cell carcinoma: analysis of a defined population. Acta Derm Venereol. 2012; 93(4):417-21. DOI: 10.2340/00015555-1501. View

12.

Hait N, Maiti A, Wu R, Andersen V, Hsu C, Wu Y . Extracellular sialyltransferase st6gal1 in breast tumor cell growth and invasiveness. Cancer Gene Ther. 2022; 29(11):1662-1675. PMC: 9663294. DOI: 10.1038/s41417-022-00485-y. View

13.

Ma K, Lee C, Liu K, Cheng-Chung Wei J, Lee Y, Wang L . Safety and Seroconversion of Immunotherapies against SARS-CoV-2 Infection: A Systematic Review and Meta-Analysis of Clinical Trials. Pathogens. 2021; 10(12). PMC: 8706687. DOI: 10.3390/pathogens10121537. View

14.

Panachan J, Rojsirikulchai N, Pongsakul N, Khowawisetsut L, Pongphitcha P, Siriboonpiputtana T . Extracellular Vesicle-Based Method for Detecting Amplification Status of Pediatric Neuroblastoma. Cancers (Basel). 2022; 14(11). PMC: 9179557. DOI: 10.3390/cancers14112627. View

15.

Kumeda N, Ogawa Y, Akimoto Y, Kawakami H, Tsujimoto M, Yanoshita R . Characterization of Membrane Integrity and Morphological Stability of Human Salivary Exosomes. Biol Pharm Bull. 2017; 40(8):1183-1191. DOI: 10.1248/bpb.b16-00891. View

16.

Geidel G, Heidrich I, Kott J, Schneider S, Pantel K, Gebhardt C . Emerging precision diagnostics in advanced cutaneous squamous cell carcinoma. NPJ Precis Oncol. 2022; 6(1):17. PMC: 8943023. DOI: 10.1038/s41698-022-00261-z. View

17.

Chiang C, Tang P, Lee G, Chiang T, Chiang C, Ma K . Prevalence of Nontuberculous Mycobacterium Infections versus Tuberculosis among Autopsied HIV Patients in Sub-Saharan Africa: A Systematic Review and Meta-Analysis. Am J Trop Med Hyg. 2020; 104(2):628-633. PMC: 7866320. DOI: 10.4269/ajtmh.20-0973. View

18.

Overmiller A, McGuinn K, Roberts B, Cooper F, Brennan-Crispi D, Deguchi T . c-Src/Cav1-dependent activation of the EGFR by Dsg2. Oncotarget. 2016; 7(25):37536-37555. PMC: 5122330. DOI: 10.18632/oncotarget.7675. View

19.

Flemming J, Hill B, Haque M, Raad J, Bonder C, Harshyne L . miRNA- and cytokine-associated extracellular vesicles mediate squamous cell carcinomas. J Extracell Vesicles. 2020; 9(1):1790159. PMC: 7480578. DOI: 10.1080/20013078.2020.1790159. View

20.

Lak N, van der Kooi E, Enciso-Martinez A, Lozano-Andres E, Otto C, Wauben M . Extracellular Vesicles: A New Source of Biomarkers in Pediatric Solid Tumors? A Systematic Review. Front Oncol. 2022; 12:887210. PMC: 9173703. DOI: 10.3389/fonc.2022.887210. View