Diverse and Composite Roles of MiRNA in Non-Neuronal Cells and Neuronal Synapses in Alzheimer's Disease

Overview

Journal Biomolecules

Publisher MDPI

Specialties Biochemistry
Molecular Biology

Date 2022 Oct 27

PMID 36291714

Authors

Xinrong Li

Shih-Chi Chen

Jacque Pak Kan Ip

Affiliations

Soon will be listed here.

Abstract

Neurons interact with astrocytes, microglia, and vascular cells. These interactions become unbalanced in disease states, resulting in damage to neurons and synapses, and contributing to cognitive impairment. Importantly, synaptic loss and synaptic dysfunction have been considered for years as a main pathological factor of cognitive impairment in Alzheimer's disease (AD). Recently, miRNAs have emerged as essential regulators of physiological and pathological processes in the brain. Focusing on the role of miRNAs in regulating synaptic functions, as well as different cell types in the brain, offers opportunities for the early prevention, diagnosis, and potential treatment of AD-related cognitive impairment. Here, we review the recent research conducted on miRNAs regulating astrocytes, microglia, cerebrovasculature, and synaptic functions in the context of AD-related cognitive impairment. We also review potential miRNA-related biomarkers and therapeutics, as well as emerging imaging technologies relevant for AD research.

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References

Chuang Y, An Y, Bilgel M, Wong D, Troncoso J, OBrien R . Midlife adiposity predicts earlier onset of Alzheimer's dementia, neuropathology and presymptomatic cerebral amyloid accumulation. Mol Psychiatry. 2015; 21(7):910-5. PMC: 5811225. DOI: 10.1038/mp.2015.129. View

Lamanna J, Harik S . Regional comparisons of brain glucose influx. Brain Res. 1985; 326(2):299-305. DOI: 10.1016/0006-8993(85)90039-3. View

Bilen J, Liu N, Burnett B, Pittman R, Bonini N . MicroRNA pathways modulate polyglutamine-induced neurodegeneration. Mol Cell. 2006; 24(1):157-63. DOI: 10.1016/j.molcel.2006.07.030. View

Bazrgar M, Khodabakhsh P, Mohagheghi F, Prudencio M, Ahmadiani A . Brain microRNAs dysregulation: Implication for missplicing and abnormal post-translational modifications of tau protein in Alzheimer's disease and related tauopathies. Pharmacol Res. 2020; 155:104729. DOI: 10.1016/j.phrs.2020.104729. View

Luarte A, Henzi R, Fernandez A, Gaete D, Cisternas P, Pizarro M . Astrocyte-Derived Small Extracellular Vesicles Regulate Dendritic Complexity through miR-26a-5p Activity. Cells. 2020; 9(4). PMC: 7226994. DOI: 10.3390/cells9040930. View

Chan V, Sun Z, Tang S, Chen L, Wong A, Tham C . Spectral-Domain OCT Measurements in Alzheimer's Disease: A Systematic Review and Meta-analysis. Ophthalmology. 2018; 126(4):497-510. PMC: 6424641. DOI: 10.1016/j.ophtha.2018.08.009. View

Wang X, Liu D, Huang H, Wang Z, Hou T, Yang X . A Novel MicroRNA-124/PTPN1 Signal Pathway Mediates Synaptic and Memory Deficits in Alzheimer's Disease. Biol Psychiatry. 2017; 83(5):395-405. DOI: 10.1016/j.biopsych.2017.07.023. View

Lim L, Lau N, Garrett-Engele P, Grimson A, Schelter J, Castle J . Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs. Nature. 2005; 433(7027):769-73. DOI: 10.1038/nature03315. View

Guo T, Noble W, Hanger D . Roles of tau protein in health and disease. Acta Neuropathol. 2017; 133(5):665-704. PMC: 5390006. DOI: 10.1007/s00401-017-1707-9. View

10.

Chiareli R, Carvalho G, Marques B, Mota L, Oliveira-Lima O, Gomes R . The Role of Astrocytes in the Neurorepair Process. Front Cell Dev Biol. 2021; 9:665795. PMC: 8186445. DOI: 10.3389/fcell.2021.665795. View

11.

Bell R, Sagare A, Friedman A, Bedi G, Holtzman D, Deane R . Transport pathways for clearance of human Alzheimer's amyloid beta-peptide and apolipoproteins E and J in the mouse central nervous system. J Cereb Blood Flow Metab. 2006; 27(5):909-18. PMC: 2853021. DOI: 10.1038/sj.jcbfm.9600419. View

12.

Dugger B, Dickson D . Pathology of Neurodegenerative Diseases. Cold Spring Harb Perspect Biol. 2017; 9(7). PMC: 5495060. DOI: 10.1101/cshperspect.a028035. View

13.

Chen S, Sun H, Zhang Y, Xu H, Yang Y, Wang F . Effects of acupuncture at Baihui (GV 20) and Zusanli (ST 36) on peripheral serum expression of MicroRNA 124, laminin and integrin β1 in rats with cerebral ischemia reperfusion injury. Chin J Integr Med. 2015; 22(1):49-55. DOI: 10.1007/s11655-015-2112-7. View

14.

Shi Q, Chowdhury S, Ma R, Le K, Hong S, Caldarone B . Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice. Sci Transl Med. 2017; 9(392). PMC: 6936623. DOI: 10.1126/scitranslmed.aaf6295. View

15.

Shi Z, Zhang K, Zhou H, Jiang L, Xie B, Wang R . Increased miR-34c mediates synaptic deficits by targeting synaptotagmin 1 through ROS-JNK-p53 pathway in Alzheimer's Disease. Aging Cell. 2020; 19(3):e13125. PMC: 7059146. DOI: 10.1111/acel.13125. View

16.

Bazrgar M, Khodabakhsh P, Prudencio M, Mohagheghi F, Ahmadiani A . The role of microRNA-34 family in Alzheimer's disease: A potential molecular link between neurodegeneration and metabolic disorders. Pharmacol Res. 2021; 172:105805. DOI: 10.1016/j.phrs.2021.105805. View

17.

Zhang E, Richards H, Kida S, Weller R . Directional and compartmentalised drainage of interstitial fluid and cerebrospinal fluid from the rat brain. Acta Neuropathol. 1992; 83(3):233-9. DOI: 10.1007/BF00296784. View

18.

Heo C, Kim K, Kim H, Baik S, Song H, Kim Y . A two-photon fluorescent probe for amyloid-β plaques in living mice. Chem Commun (Camb). 2013; 49(13):1303-5. DOI: 10.1039/c2cc38570h. View

19.

Peng L, Bestard-Lorigados I, Song W . The synapse as a treatment avenue for Alzheimer's Disease. Mol Psychiatry. 2022; 27(7):2940-2949. DOI: 10.1038/s41380-022-01565-z. View

20.

Weller R, Massey A, Newman T, Hutchings M, Kuo Y, Roher A . Cerebral amyloid angiopathy: amyloid beta accumulates in putative interstitial fluid drainage pathways in Alzheimer's disease. Am J Pathol. 1998; 153(3):725-33. PMC: 1853019. DOI: 10.1016/s0002-9440(10)65616-7. View