Astaxanthin Is Able to Prevent Alcohol-Induced Dysfunction of Liver Mitochondria

Overview

Journal Antioxidants (Basel)

Date 2022 Oct 27

PMID 36290741

Authors

Olga Krestinina

Irina Odinokova

Linda Sotnikova

Roman Krestinin

Alena Zvyagina

Yulia Baburina

Affiliations

Soon will be listed here.

Abstract

The search for new targets for the pathological action of ethanol remains an urgent task of biomedicine. Since degenerative changes in the liver are associated with the development of oxidative stress, antioxidants are promising agents for the treatment of alcohol-related diseases. In this work, we studied the ability of the carotenoid antioxidant, astaxanthin (AX), to prevent ethanol-induced changes in the liver of rats. It was shown that AX is able to protect the structure of mitochondria from degenerative changes caused by ethanol to improve mitochondrial functions. AX positively influences the activity and expression of proteins of the mitochondrial respiratory chain complexes and ATPase. In addition, a protective effect of AX on the rate and activity of mitochondrial respiration was demonstrated in the work. Thus, studies have shown that AX is involved in protective mechanisms in response to ethanol-induced mitochondrial dysfunction.

References

Krestinina O, Baburina Y, Krestinin R, Odinokova I, Fadeeva I, Sotnikova L . Astaxanthin Prevents Mitochondrial Impairment Induced by Isoproterenol in Isolated Rat Heart Mitochondria. Antioxidants (Basel). 2020; 9(3). PMC: 7139515. DOI: 10.3390/antiox9030262. View

Mantena S, King A, Andringa K, Eccleston H, Bailey S . Mitochondrial dysfunction and oxidative stress in the pathogenesis of alcohol- and obesity-induced fatty liver diseases. Free Radic Biol Med. 2008; 44(7):1259-72. PMC: 2323912. DOI: 10.1016/j.freeradbiomed.2007.12.029. View

Miyazawa N, Hamel E, Diksic M . Assessment of the peripheral benzodiazepine receptors in human gliomas by two methods. J Neurooncol. 1998; 38(1):19-26. DOI: 10.1023/a:1005933226966. View

Nishida Y, Nawaz A, Hecht K, Tobe K . Astaxanthin as a Novel Mitochondrial Regulator: A New Aspect of Carotenoids, beyond Antioxidants. Nutrients. 2022; 14(1). PMC: 8746862. DOI: 10.3390/nu14010107. View

Hoek J, Cahill A, Pastorino J . Alcohol and mitochondria: a dysfunctional relationship. Gastroenterology. 2002; 122(7):2049-63. PMC: 1868435. DOI: 10.1053/gast.2002.33613. View

Rosa M, Sa-Correia I . In vivo activation by ethanol of plasma membrane ATPase of Saccharomyces cerevisiae. Appl Environ Microbiol. 1991; 57(3):830-5. PMC: 182802. DOI: 10.1128/aem.57.3.830-835.1991. View

McDonough K . Antioxidant nutrients and alcohol. Toxicology. 2003; 189(1-2):89-97. DOI: 10.1016/s0300-483x(03)00155-0. View

Baburina Y, Odinokova I, Azarashvili T, Akatov V, Lemasters J, Krestinina O . 2',3'-Cyclic nucleotide 3'-phosphodiesterase as a messenger of protection of the mitochondrial function during melatonin treatment in aging. Biochim Biophys Acta Biomembr. 2016; 1859(1):94-103. PMC: 5539527. DOI: 10.1016/j.bbamem.2016.11.003. View

Ma L, Dong J, Wu C, Li X, Chen J, Zhang H . Spectroscopic, Polarographic, and Microcalorimetric Studies on Mitochondrial Dysfunction Induced by Ethanol. J Membr Biol. 2017; 250(2):195-204. DOI: 10.1007/s00232-017-9947-0. View

10.

Rasic-Markovic A, Krstic D, Vujovic Z, Jakovljevic V, Stanojlovic O, Hrncic D . Modulations of rabbit erythrocyte ATPase activities induced by in vitro and in vivo exposure to ethanol. Mol Cell Biochem. 2007; 308(1-2):111-6. DOI: 10.1007/s11010-007-9618-z. View

11.

Guo C, Sun L, Chen X, Zhang D . Oxidative stress, mitochondrial damage and neurodegenerative diseases. Neural Regen Res. 2014; 8(21):2003-14. PMC: 4145906. DOI: 10.3969/j.issn.1673-5374.2013.21.009. View

12.

Thai P, Daugherty D, Frederich B, Lu X, Deng W, Bers D . Cardiac-specific Conditional Knockout of the 18-kDa Mitochondrial Translocator Protein Protects from Pressure Overload Induced Heart Failure. Sci Rep. 2018; 8(1):16213. PMC: 6212397. DOI: 10.1038/s41598-018-34451-2. View

13.

Zhang Z, Wang B, Hu Q, Sommerfeld M, Li Y, Han D . A new paradigm for producing astaxanthin from the unicellular green alga Haematococcus pluvialis. Biotechnol Bioeng. 2016; 113(10):2088-99. PMC: 5071682. DOI: 10.1002/bit.25976. View

14.

Louvet A, Mathurin P . Alcoholic liver disease: mechanisms of injury and targeted treatment. Nat Rev Gastroenterol Hepatol. 2015; 12(4):231-42. DOI: 10.1038/nrgastro.2015.35. View

15.

Grattagliano I, Russmann S, Diogo C, Bonfrate L, Oliveira P, Wang D . Mitochondria in chronic liver disease. Curr Drug Targets. 2011; 12(6):879-93. DOI: 10.2174/138945011795528877. View

16.

Cederbaum A, Lu Y, Wu D . Role of oxidative stress in alcohol-induced liver injury. Arch Toxicol. 2009; 83(6):519-48. DOI: 10.1007/s00204-009-0432-0. View

17.

Manzo-Avalos S, Saavedra-Molina A . Cellular and mitochondrial effects of alcohol consumption. Int J Environ Res Public Health. 2011; 7(12):4281-304. PMC: 3037055. DOI: 10.3390/ijerph7124281. View

18.

Sadrzadeh S, Price P, Nanji A . Ethanol-induced changes in membrane ATPases: inhibition by iron chelation. Biochem Pharmacol. 1994; 47(4):745-7. DOI: 10.1016/0006-2952(94)90139-2. View

19.

Reiser G, Kunzelmann U, Steinhilber G, Binmoller F . Generation of a monoclonal antibody against the myelin protein CNP (2',3'-cyclic nucleotide 3'-phosphodiesterase) suitable for biochemical and for immunohistochemical investigations of CNP. Neurochem Res. 1994; 19(12):1479-85. DOI: 10.1007/BF00968994. View

20.

Kikukawa H, Shimizu C, Hirono-Hara Y, Hara K . Effect of ethanol on astaxanthin and fatty acid production in the red yeast Xanthophyllomyces dendrorhous. J Appl Microbiol. 2021; 132(3):2034-2041. DOI: 10.1111/jam.15335. View