Trends in Gliosis in Obesity, and the Role of Antioxidants As a Therapeutic Alternative

Overview

Journal Antioxidants (Basel)

Date 2022 Oct 27

PMID 36290695

Authors

Cindy Bandala

Noemi Cardenas-Rodriguez

Samuel Reyes-Long

Jose Luis Cortes-Altamirano

David Garciadiego-Cazares

Eleazar Lara-Padilla

Gabriela Ibanez-Cervantes

Javier Mancilla-Ramirez

Saul Gomez-Manzo

Alfonso Alfaro-Rodriguez

Affiliations

Soon will be listed here.

Abstract

Aim: Identify the immunological and oxidative stress mechanisms that produce gliosis in patients with obesity and propose antioxidants as an alternative to reducing neuroinflammation.

Method: Advanced searches were performed in scientific databases: PubMed, ProQuest, EBSCO, and the Science Citation index for research on the physiopathology of gliosis in obese patients and for the possible role of antioxidants in its management.

Conclusion: Patients with obesity can develop neuroinflammation, conditioned by various adipokines, excess lipids and glucose, which results in an increase in free radicals that must be neutralized with antioxidants to reduce gliosis and the risk of long-term neurodegeneration.

Citing Articles

Dysregulation of Metabolic Peptides in the Gut-Brain Axis Promotes Hyperinsulinemia, Obesity, and Neurodegeneration.

Green C, Zaman V, Blumenstock K, Banik N, Haque A Biomedicines. 2025; 13(1).

PMID: 39857716 PMC: 11763097. DOI: 10.3390/biomedicines13010132.

Ldlr-/-.Leiden mice develop neurodegeneration, age-dependent astrogliosis and obesity-induced changes in microglia immunophenotype which are partly reversed by complement component 5 neutralizing antibody.

Seidel F, Fluiter K, Kleemann R, Worms N, van Nieuwkoop A, Caspers M Front Cell Neurosci. 2023; 17:1205261.

PMID: 37457817 PMC: 10346859. DOI: 10.3389/fncel.2023.1205261.

Effect of Obesity and Osteocalcin on Brain Glucose Metabolism in Healthy Participants.

Shin S, Nam H Brain Sci. 2023; 13(6).

PMID: 37371372 PMC: 10296109. DOI: 10.3390/brainsci13060889.

ROS-Induced DNA-Damage and Autophagy in Oral Squamous Cell Carcinoma by Oil Extract-An In Vitro Study.

Popovici V, Musuc A, Matei E, Karampelas O, Ozon E, Cozaru G Int J Mol Sci. 2022; 23(23).

PMID: 36499160 PMC: 9738295. DOI: 10.3390/ijms232314836.

References

Barroso Spejo A, Teles C, Zuccoli G, de Oliveira A . Synapse preservation and decreased glial reactions following ventral root crush (VRC) and treatment with 4-hydroxy-tempo (TEMPOL). J Neurosci Res. 2018; 97(4):520-534. DOI: 10.1002/jnr.24365. View

Li L, Fan Y, Wu W, Bai C, Jia M, Hu J . Novel melatonin-trientine conjugate as potential therapeutic agents for Alzheimer's disease. Bioorg Chem. 2022; 128:106100. DOI: 10.1016/j.bioorg.2022.106100. View

Tomassoni D, Nwankwo I, Gabrielli M, Bhatt S, Muhammad A, Lokhandwala M . Astrogliosis in the brain of obese Zucker rat: a model of metabolic syndrome. Neurosci Lett. 2013; 543:136-41. DOI: 10.1016/j.neulet.2013.03.025. View

Vuong B, Odero G, Rozbacher S, Stevenson M, Kereliuk S, Pereira T . Exposure to gestational diabetes mellitus induces neuroinflammation, derangement of hippocampal neurons, and cognitive changes in rat offspring. J Neuroinflammation. 2017; 14(1):80. PMC: 5384149. DOI: 10.1186/s12974-017-0859-9. View

Ridet J, Alonso G, Chauvet N, Chapron J, Koenig J, Privat A . Immunocytochemical characterization of a new marker of fibrous and reactive astrocytes. Cell Tissue Res. 1996; 283(1):39-49. DOI: 10.1007/s004410050510. View

Hsieh C, Wang Y, Lin P, Peng S, Chou M . Seed peptide lunasin ameliorates obesity-induced inflammation and regulates immune responses in C57BL/6J mice fed high-fat diet. Food Chem Toxicol. 2020; 147:111908. DOI: 10.1016/j.fct.2020.111908. View

Bian M, Du X, Cui J, Wang P, Wang W, Zhu W . Celastrol protects mouse retinas from bright light-induced degeneration through inhibition of oxidative stress and inflammation. J Neuroinflammation. 2016; 13:50. PMC: 4769581. DOI: 10.1186/s12974-016-0516-8. View

Khorshidi M, Moini A, Alipoor E, Rezvan N, Gorgani-Firuzjaee S, Yaseri M . The effects of quercetin supplementation on metabolic and hormonal parameters as well as plasma concentration and gene expression of resistin in overweight or obese women with polycystic ovary syndrome. Phytother Res. 2018; 32(11):2282-2289. DOI: 10.1002/ptr.6166. View

Mendes N, Velloso L . Perivascular macrophages in high-fat diet-induced hypothalamic inflammation. J Neuroinflammation. 2022; 19(1):136. PMC: 9185933. DOI: 10.1186/s12974-022-02519-6. View

10.

Fernandez-Felipe J, Valencia-Avezuela M, Merino B, Somoza B, Cano V, Sanz-Martos A . Effects of saturated versus unsaturated fatty acids on metabolism, gliosis, and hypothalamic leptin sensitivity in male mice. Nutr Neurosci. 2022; 26(2):173-186. DOI: 10.1080/1028415X.2022.2029294. View

11.

Olayinka J, Eduviere A, Adeoluwa O, Fafure A, Adebanjo A, Ozolua R . Quercetin mitigates memory deficits in scopolamine mice model via protection against neuroinflammation and neurodegeneration. Life Sci. 2022; 292:120326. DOI: 10.1016/j.lfs.2022.120326. View

12.

OBrien P, Hinder L, Callaghan B, Feldman E . Neurological consequences of obesity. Lancet Neurol. 2017; 16(6):465-477. PMC: 5657398. DOI: 10.1016/S1474-4422(17)30084-4. View

13.

Setkowicz Z, Gazdzinska A, Osoba J, Karwowska K, Majka P, Orzel J . Does Long-Term High Fat Diet Always Lead to Smaller Hippocampi Volumes, Metabolite Concentrations, and Worse Learning and Memory? A Magnetic Resonance and Behavioral Study in Wistar Rats. PLoS One. 2015; 10(10):e0139987. PMC: 4598109. DOI: 10.1371/journal.pone.0139987. View

14.

Lainez N, Coss D . Obesity, Neuroinflammation, and Reproductive Function. Endocrinology. 2019; 160(11):2719-2736. PMC: 6806266. DOI: 10.1210/en.2019-00487. View

15.

Tan S, Deliyanti D, Figgett W, Talia D, de Haan J, Wilkinson-Berka J . Ebselen by modulating oxidative stress improves hypoxia-induced macroglial Müller cell and vascular injury in the retina. Exp Eye Res. 2015; 136:1-8. DOI: 10.1016/j.exer.2015.04.015. View

16.

Forny-Germano L, De Felice F, Vieira M . The Role of Leptin and Adiponectin in Obesity-Associated Cognitive Decline and Alzheimer's Disease. Front Neurosci. 2019; 12:1027. PMC: 6340072. DOI: 10.3389/fnins.2018.01027. View

17.

Molteni R, Wu A, Vaynman S, Ying Z, Barnard R, Gomez-Pinilla F . Exercise reverses the harmful effects of consumption of a high-fat diet on synaptic and behavioral plasticity associated to the action of brain-derived neurotrophic factor. Neuroscience. 2003; 123(2):429-40. DOI: 10.1016/j.neuroscience.2003.09.020. View

18.

Cesar H, Pisani L . Fatty-acid-mediated hypothalamic inflammation and epigenetic programming. J Nutr Biochem. 2016; 42:1-6. DOI: 10.1016/j.jnutbio.2016.08.008. View

19.

Balland E, Chen W, Dodd G, Conductier G, Coppari R, Tiganis T . Leptin Signaling in the Arcuate Nucleus Reduces Insulin's Capacity to Suppress Hepatic Glucose Production in Obese Mice. Cell Rep. 2019; 26(2):346-355.e3. DOI: 10.1016/j.celrep.2018.12.061. View

20.

Amer M, Karam R . Morphological and Biochemical Features of Cerebellar Cortex After Exposure to Zinc Oxide Nanoparticles: Possible Protective Role of Curcumin. Anat Rec (Hoboken). 2018; 301(8):1454-1466. DOI: 10.1002/ar.23807. View