Engineering Approaches for the Development of Antimicrobial Peptide-Based Antibiotics

Overview

Journal Antibiotics (Basel)

Specialty Pharmacology

Date 2022 Oct 27

PMID 36289996

Authors

Su-Jin Kang

So Hee Nam

Bong-Jin Lee

Affiliations

Soon will be listed here.

Abstract

Antimicrobial peptides (AMPs) have received increasing attention as potential alternatives for future antibiotics because of the rise of multidrug-resistant (MDR) bacteria. AMPs are small cationic peptides with broad-spectrum antibiotic activities and different action mechanisms to those of traditional antibiotics. Despite the desirable advantages of developing peptide-based antimicrobial agents, the clinical applications of AMPs are still limited because of their enzymatic degradation, toxicity, and selectivity. In this review, structural modifications, such as amino acid substitution, stapling, cyclization of peptides, and hybrid AMPs with conventional antibiotics or other peptides, will be presented. Additionally, nanodelivery systems using metals or lipids to deliver AMPs will be discussed based on the structural properties and action mechanisms of AMPs.

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