Low Somatomedin-C (Sm-C) Concentrations Measured by Direct Radioimmunoassay in Patients with Chronic Renal Failure

Ten patients suffering from chronic renal failure and undergoing regular hemodialysis were tested immediately before and immediately after a 3-hour dialysis. Serum levels of immunoreactive Sm-C, estimated on unextracted non acidified serum at non equilibrium, were significantly lower than in normal controls and no consistent modifications were observed after dialysis.