Catalytic Transfer Hydrogenation of N to NH Via a Photoredox Catalysis Strategy

Overview

Journal Sci Adv

Specialties Biology
Science

Date 2022 Oct 26

PMID 36288295

Authors

Christian M Johansen

Emily A Boyd

Jonas C Peters

Affiliations

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Abstract

Inspired by momentum in applications of reductive photoredox catalysis to organic synthesis, photodriven transfer hydrogenations toward deep (>2 e) reductions of small molecules are attractive compared to using harsh chemical reagents. Noteworthy in this context is the nitrogen reduction reaction (NRR), where a synthetic photocatalyst system had yet to be developed. Noting that a reduced Hantzsch ester (HEH) and related organic structures can behave as 2 e/2 H photoreductants, we show here that, when partnered with a suitable catalyst (Mo) under blue light irradiation, HEH facilitates delivery of successive H equivalents for the 6 e/6 H catalytic reduction of N to NH; this catalysis is enhanced by addition of a photoredox catalyst (Ir). Reductions of additional substrates (nitrate and acetylene) are also described.

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