Serum Level of Inhibin B and Kisspeptin, As Well As Their Correlation with Biochemical Factors in Obese Adult Patients

Overview

Journal Arch Razi Inst

Specialties Allergy & Immunology
General Medicine
Veterinary Medicine

Date 2022 Oct 26

PMID 36284976

Authors

S A Ibrahim

A A Adnan

S T Gahzi

Affiliations

Soon will be listed here.

Abstract

Obesity is one of the most important global health problems causing serious health risks and early death in human. It is also associated with disturbance of homeostasis of hormones and immunological biochemical factors inside the human body. This study aimed to evaluate the serum level of inhibin B and kisspeptin among Iraqi obese adult people and other biochemical parameters correlated with obesity. Inhibin B and levels of kisspeptin were evaluated in the samples of serum from 40 Iraqi obese adult patients and 30 healthy non-obese individuals. A significant decrease (<0.0001) was observed in the kisspeptin level in both males and females, compared to the control group. Moreover, inhibin B decreased significantly in obese females only (<0.001), while there was no differences between males and the control group in this regard. Finally, body mass index, serum glutamic pyruvic transaminase (SGPT), and leptin showed negative correlation with kisspeptin (0.01, 0.5, and 0.01), respectively. However, a positive association was observed with the level of Ca in the serum. On the other hand, inhibin B confirmed a positive correlation with SGPT. The present study revealed a significant increase in inhibin B and kisspeptin, with SGPT and Ca in the serum of obese patients, which could lead to complications and health problems among these patients.

References

Du Plessis S, Cabler S, McAlister D, Sabanegh E, Agarwal A . The effect of obesity on sperm disorders and male infertility. Nat Rev Urol. 2010; 7(3):153-61. DOI: 10.1038/nrurol.2010.6. View

Hestiantoro A, Astuti B, Muharam R, Pratama G, Witjaksono F, Wiweko B . Dysregulation of Kisspeptin and Leptin, as Anorexigenic Agents, Plays Role in the Development of Obesity in Postmenopausal Women. Int J Endocrinol. 2019; 2019:1347208. PMC: 6913251. DOI: 10.1155/2019/1347208. View

De Bond J, Smith J . Kisspeptin and energy balance in reproduction. Reproduction. 2013; 147(3):R53-63. DOI: 10.1530/REP-13-0509. View

Fabian U, Charles-Davies M, Fasanmade A, Olaniyi J, Oyewole O, Owolabi M . Male Sexual Dysfunction, Leptin, Pituitary and Gonadal Hormones in Nigerian Males with Metabolic Syndrome and Type 2 Diabetes Mellitus. J Reprod Infertil. 2016; 17(1):17-25. PMC: 4769850. View

Quennell J, Howell C, Roa J, Augustine R, Grattan D, Anderson G . Leptin deficiency and diet-induced obesity reduce hypothalamic kisspeptin expression in mice. Endocrinology. 2011; 152(4):1541-50. PMC: 3206710. DOI: 10.1210/en.2010-1100. View

Reis F, De Rezende C . [Clinical usefulness of inhibin assays in gynecology and obstetrics]. Rev Bras Ginecol Obstet. 2010; 31(12):621-5. View

Cortet-Rudelli C, Pigny P, Decanter C, Leroy M, Maunoury-Lefebvre C, Thomas-Desrousseaux P . Obesity and serum luteinizing hormone level have an independent and opposite effect on the serum inhibin B level in patients with polycystic ovary syndrome. Fertil Steril. 2002; 77(2):281-7. DOI: 10.1016/s0015-0282(01)02968-5. View

Globerman H, Shen-Orr Z, Karnieli E, Aloni Y, Charuzi I . Inhibin B in men with severe obesity and after weight reduction following gastroplasty. Endocr Res. 2005; 31(1):17-26. DOI: 10.1080/07435800500228971. View

Rance N . Menopause and the human hypothalamus: evidence for the role of kisspeptin/neurokinin B neurons in the regulation of estrogen negative feedback. Peptides. 2008; 30(1):111-22. PMC: 2632595. DOI: 10.1016/j.peptides.2008.05.016. View

10.

Crujeiras A, Carreira M, Cabia B, Andrade S, Amil M, Casanueva F . Leptin resistance in obesity: An epigenetic landscape. Life Sci. 2015; 140:57-63. DOI: 10.1016/j.lfs.2015.05.003. View

11.

Bilezikjian L, Blount A, Donaldson C, Vale W . Pituitary actions of ligands of the TGF-beta family: activins and inhibins. Reproduction. 2006; 132(2):207-15. DOI: 10.1530/rep.1.01073. View

12.

Chambers T, Richard R . The impact of obesity on male fertility. Hormones (Athens). 2016; 14(4):563-8. DOI: 10.14310/horm.2002.1621. View

13.

Hayes F, Hall J, Boepple P, Crowley Jr W . Clinical review 96: Differential control of gonadotropin secretion in the human: endocrine role of inhibin. J Clin Endocrinol Metab. 1998; 83(6):1835-41. DOI: 10.1210/jcem.83.6.4884. View

14.

Babwah A, Pampillo M, Min L, Kaiser U, Bhattacharya M . Single-cell analyses reveal that KISS1R-expressing cells undergo sustained kisspeptin-induced signaling that is dependent upon an influx of extracellular Ca2+. Endocrinology. 2012; 153(12):5875-87. PMC: 3512071. DOI: 10.1210/en.2012-1747. View

15.

Wolfe A, Hussain M . The Emerging Role(s) for Kisspeptin in Metabolism in Mammals. Front Endocrinol (Lausanne). 2018; 9:184. PMC: 5928256. DOI: 10.3389/fendo.2018.00184. View

16.

Makanji Y, Zhu J, Mishra R, Holmquist C, Wong W, Schwartz N . Inhibin at 90: from discovery to clinical application, a historical review. Endocr Rev. 2014; 35(5):747-94. PMC: 4167436. DOI: 10.1210/er.2014-1003. View

17.

Harter C, Kavanagh G, Smith J . The role of kisspeptin neurons in reproduction and metabolism. J Endocrinol. 2018; 238(3):R173-R183. DOI: 10.1530/JOE-18-0108. View