Left-sided Colorectal Cancer Distinct in Indigenous African Patients Compared to Other Ethnic Groups in South Africa

Overview

Journal BMC Cancer

Publisher Biomed Central

Specialty Oncology

Date 2022 Oct 25

PMID 36280820

Authors

Michelle McCabe

Clement Penny

Pumza Magangane

Sheefa Mirza

Yvonne Perner

Affiliations

Soon will be listed here.

Abstract

Introduction: A large proportion of indigenous African (IA) colorectal cancer (CRC) patients in South Africa are young (< 50 years), with no unique histopathological or molecular characteristics. Anatomical site as well as microsatellite instability (MSI) status have shown to be associated with different clinicopathological and molecular features. This study aimed to ascertain key histopathological features in microsatellite stable (MSS) and low-frequency MSI (MSI-L) patients, to provide insight into the mechanism of the disease.

Methods: A retrospective cohort (2011-2015) of MSS/MSI-L CRC patient samples diagnosed at Charlotte Maxeke Johannesburg Academic Hospital was analyzed. Samples were categorized by site [right colon cancer (RCC) versus left (LCC)], ethnicity [IA versus other ethnic groups (OEG)] and MSI status (MSI-L vs MSS). T-test, Fischer's exact and Chi-square tests were conducted.

Results: IA patients with LCC demonstrated an increased prevalence in males, sigmoid colon, signet-ring-cell morphology, MSI-L with BAT25/26 marker instability and advanced disease association.

Conclusion: This study revealed distinct histopathological features for LCC, and suggests BAT25 and BAT26 as negative prognostic markers in African CRC patients. Larger confirmatory studies are recommended.

Citing Articles

Genetic insights: High germline variant rate in an indigenous African cohort with early-onset colorectal cancer.

Yildiz S, Musarurwa T, Algar U, Chambuso R, Rebello G, Goldberg P Front Oncol. 2023; 13:1253867.

PMID: 37965459 PMC: 10642181. DOI: 10.3389/fonc.2023.1253867.

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