The Association of Cytomegalovirus IgM and Allostatic Load

Overview

Journal Diseases

Date 2022 Oct 24

PMID 36278569

Authors

Matthew Hill

Emmanuel Obeng-Gyasi

Affiliations

Soon will be listed here.

Abstract

Background: Cytomegalovirus (CMV) is a deoxyribonucleic acid virus that affects a significant proportion of the worldwide population; after primary infection, it goes into a latent state and can be reactivated, primarily after a reduction in host immune defenses.

Methods: This study evaluated the association of acute cytomegalovirus infection (CMV IgM) and Allostatic Load (AL) by sociodemographic factors using data from the National Health and Nutrition Examination Survey (NHANES) 2001-2004 among participants (aged 20-49 years). CMV infection was determined by the level of CMV IgM antibody in serum samples. AL was assessed as a combination of 10 biomarkers from the cardiovascular, inflammatory, and metabolic systems. The evaluation of the association between CMV infection and AL included descriptive statistics and logistic regression models, which were adjusted for demographic and behavioral covariates.

Results: AL was more elevated among those who were older, male, those with lower education, those performing limited physical activity, and smokers. CMV was more elevated in females than males among those who consumed alcohol and cigarette smokers. In Pearson's correlation analysis, there was a slight positive correlation between CMV IgM and AL, with triglycerides and Body Mass Index (BMI) the most strongly correlated with AL. Binary logistic regression showed no significant relationship between high AL and positive CMV IgM but did show a significant relationship between high AL and age (OR = 1.0592, 95% CI 1.0215-1.0983, = 0.00715). The findings of this study provide insight into the relationship between CMV and AL and provide awareness of factors that affect their relationship.

Citing Articles

Associations of Socioeconomic Factors and Unhealthy Lifestyles with Allostatic Load: A Meta-analysis.

Yuan D, Wang M, Bu S, Mu T, Li Y Int J Behav Med. 2023; 31(5):772-786.

PMID: 37889389 DOI: 10.1007/s12529-023-10235-5.

The Association of Cytomegalovirus and Allostatic Load by Country of Birth and Length of Time in the United States.

Hill M, Mostafa S, Muganda P, Jeffers-Francis L, Obeng-Gyasi E Diseases. 2023; 11(3).

PMID: 37606472 PMC: 10443278. DOI: 10.3390/diseases11030101.

Combined Effects of Multiple Per- and Polyfluoroalkyl Substances Exposure on Allostatic Load Using Bayesian Kernel Machine Regression.

Bashir T, Obeng-Gyasi E Int J Environ Res Public Health. 2023; 20(10).

PMID: 37239535 PMC: 10218030. DOI: 10.3390/ijerph20105808.

References

Bahreinian S, Ball G, Vander Leek T, Colman I, McNeil B, Becker A . Allostatic load biomarkers and asthma in adolescents. Am J Respir Crit Care Med. 2012; 187(2):144-52. DOI: 10.1164/rccm.201201-0025OC. View

Limaye A, Boeckh M . CMV in critically ill patients: pathogen or bystander?. Rev Med Virol. 2010; 20(6):372-9. PMC: 2987685. DOI: 10.1002/rmv.664. View

Bulka C, Bommarito P, Aiello A, Fry R . Cytomegalovirus seroprevalence, recurrence, and antibody levels: Associations with cadmium and lead exposures in the general United States population. Environ Epidemiol. 2020; 4(4):e100. PMC: 7423529. DOI: 10.1097/EE9.0000000000000100. View

Obeng-Gyasi E . Cumulative Effects of Low-Level Lead Exposure and Chronic Physiological Stress on Hepatic Dysfunction-A Preliminary Study. Med Sci (Basel). 2020; 8(3). PMC: 7563970. DOI: 10.3390/medsci8030030. View

Stagno S, Tinker M, Elrod C, FUCCILLO D, Cloud G, OBeirne A . Immunoglobulin M antibodies detected by enzyme-linked immunosorbent assay and radioimmunoassay in the diagnosis of cytomegalovirus infections in pregnant women and newborn infants. J Clin Microbiol. 1985; 21(6):930-5. PMC: 271820. DOI: 10.1128/jcm.21.6.930-935.1985. View

Colugnati F, Staras S, Dollard S, Cannon M . Incidence of cytomegalovirus infection among the general population and pregnant women in the United States. BMC Infect Dis. 2007; 7:71. PMC: 1925089. DOI: 10.1186/1471-2334-7-71. View

Geronimus A, Hicken M, Keene D, Bound J . "Weathering" and age patterns of allostatic load scores among blacks and whites in the United States. Am J Public Health. 2005; 96(5):826-33. PMC: 1470581. DOI: 10.2105/AJPH.2004.060749. View

Ding X, Barban N, Mills M . Educational attainment and allostatic load in later life: Evidence using genetic markers. Prev Med. 2019; 129:105866. PMC: 6913517. DOI: 10.1016/j.ypmed.2019.105866. View

van Boven M, van de Kassteele J, Korndewal M, van Dorp C, Kretzschmar M, van der Klis F . Infectious reactivation of cytomegalovirus explaining age- and sex-specific patterns of seroprevalence. PLoS Comput Biol. 2017; 13(9):e1005719. PMC: 5630159. DOI: 10.1371/journal.pcbi.1005719. View

10.

Petrovic D, Pivin E, Ponte B, Dhayat N, Pruijm M, Ehret G . Sociodemographic, behavioral and genetic determinants of allostatic load in a Swiss population-based study. Psychoneuroendocrinology. 2016; 67:76-85. DOI: 10.1016/j.psyneuen.2016.02.003. View

11.

Bashir T, Obeng-Gyasi E . The Association between Multiple Per- and Polyfluoroalkyl Substances' Serum Levels and Allostatic Load. Int J Environ Res Public Health. 2022; 19(9). PMC: 9104853. DOI: 10.3390/ijerph19095455. View

12.

Markides K, Rote S . The Healthy Immigrant Effect and Aging in the United States and Other Western Countries. Gerontologist. 2018; 59(2):205-214. DOI: 10.1093/geront/gny136. View

13.

Cawley J, Biener A, Meyerhoefer C, Ding Y, Zvenyach T, Smolarz B . Direct medical costs of obesity in the United States and the most populous states. J Manag Care Spec Pharm. 2021; 27(3):354-366. PMC: 10394178. DOI: 10.18553/jmcp.2021.20410. View

14.

Barnes L, Capuano A, Aiello A, Turner A, Yolken R, Torrey E . Cytomegalovirus infection and risk of Alzheimer disease in older black and white individuals. J Infect Dis. 2014; 211(2):230-7. PMC: 4326304. DOI: 10.1093/infdis/jiu437. View

15.

Gustafsson P, Janlert U, Theorell T, Westerlund H, Hammarstrom A . Socioeconomic status over the life course and allostatic load in adulthood: results from the Northern Swedish Cohort. J Epidemiol Community Health. 2010; 65(11):986-92. DOI: 10.1136/jech.2010.108332. View

16.

Dowd J, Haan M, Blythe L, Moore K, Aiello A . Socioeconomic gradients in immune response to latent infection. Am J Epidemiol. 2007; 167(1):112-20. DOI: 10.1093/aje/kwm247. View

17.

Crimmins E, Johnston M, Hayward M, Seeman T . Age differences in allostatic load: an index of physiological dysregulation. Exp Gerontol. 2003; 38(7):731-4. DOI: 10.1016/s0531-5565(03)00099-8. View

18.

Seeman T, Singer B, Ryff C, Love G, Levy-Storms L . Social relationships, gender, and allostatic load across two age cohorts. Psychosom Med. 2002; 64(3):395-406. DOI: 10.1097/00006842-200205000-00004. View

19.

Hamdi N, South S, Krueger R . Does education lower allostatic load? A co-twin control study. Brain Behav Immun. 2016; 56:221-9. PMC: 4917427. DOI: 10.1016/j.bbi.2016.01.014. View

20.

Agarwal A, Kumari N, Trehan A, Khadwal A, Dogra M, Gupta V . Outcome of cytomegalovirus retinitis in immunocompromised patients without Human Immunodeficiency Virus treated with intravitreal ganciclovir injection. Graefes Arch Clin Exp Ophthalmol. 2014; 252(9):1393-401. DOI: 10.1007/s00417-014-2587-5. View