ACE2 and LOX Enzyme Inhibitions of Different Lavender Essential Oils and Major Components Linalool and Camphor

Overview

Journal ACS Omega

Publisher American Chemical Society

Specialty Chemistry

Date 2022 Oct 24

PMID 36278093

Authors

Sevde Nur Biltekin

Ayse Esra Karada

Betul Demirci

Fatih Demirci

Affiliations

Soon will be listed here.

Abstract

In this present study, , , and essential oils and their main compounds linalool and camphor were evaluated for lipoxygenase enzyme (LOX) and for angiotensin converting enzyme 2 (ACE2) inhibition potential. The chemical compositions of , , and essential oils were confirmed both by gas chromatography-mass spectrometry and gas chromatography-flame ionization detection, where 22.4, 0.9, and 30.6% linalool and 17.8, 54.7, and 15% camphor were identified for each oil among other components, respectively. Enzyme inhibitory activity studies were performed at 20 μg/mL for the tested essential oils, whereas for linalool and camphor concentrations, 5 μg/mL was used. The ACE2 inhibitions of , , and essential oils were 25.4, 34.1, and 27.1%, while the LOX inhibitions were observed as 79, 49.1, and 86.7%, respectively. In addition, linalool and camphor showed remarkable ACE2 inhibition with 77.1 and 85.1%, whereas the LOX inhibition was observed at 92 and 67.2%, respectively. In conclusion of the initial findings, further detailed studies are needed to confirm the safe use.

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