Advances of Engineered Extracellular Vesicles-based Therapeutics Strategy

Overview

Journal Sci Technol Adv Mater

Specialty Biomedical Engineering

Date 2022 Oct 24

PMID 36277506

Authors

Hiroaki Komuro

Shakhlo Aminova

Katherine Lauro

Masako Harada

Affiliations

Soon will be listed here.

Abstract

Extracellular vesicles (EVs) are a heterogeneous population of lipid bilayer membrane-bound vesicles which encapsulate bioactive molecules, such as nucleic acids, proteins, and lipids. They mediate intercellular communication through transporting internally packaged molecules, making them attractive therapeutics carriers. Over the last decades, a significant amount of research has implied the potential of EVs servings as drug delivery vehicles for nuclear acids, proteins, and small molecular drugs. However, several challenges remain unresolved before the clinical application of EV-based therapeutics, including lack of specificity, stability, biodistribution, storage, large-scale manufacturing, and the comprehensive analysis of EV composition. Technical development is essential to overcome these issues and enhance the pre-clinical therapeutic effects. In this review, we summarize the current advancements in EV engineering which demonstrate their therapeutic potential.

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