Antibacterial Activity of the Micro and Nanostructures of the Optical Material Tris(8-hydroxyquinoline)aluminum and Its Application As an Antimicrobial Coating

Overview

Journal RSC Adv

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2022 Oct 24

PMID 36276042

Authors

Abdu Saeed

Aysh Y Madkhli

Rami Adel Pashameah

Noor M Bataweel

Mir Ali Razvi

Numan Salah

Affiliations

Soon will be listed here.

Abstract

Although tris(8-hydroxyquinoline)aluminum (Alq), a fluorescent optical organometallic material, is known for its applications in optoelectronics, it has only few and limited applications in the biological field. In this study, the antibacterial activity of Alq micro and nanostructures was investigated. We prepared Alq nanostructures. We prepared nanosized Alq as rice-like structures that assembled into flower shapes with an α-crystal phase. Then, Alq micro and nanostructure antibacterial activities were estimated against seven human pathogenic bacterial strains. Besides, we compared their antibacterial activities with those of standard antibiotics. The minimal inhibitory concentration (MIC), minimum bactericidal concentration (MBC), and IC50 were evaluated. Alq micro and nanostructure antibacterial activity showed considerable values compared to standard antibiotics. Besides, the obtained data revealed that the antibacterial activity of Alq in nanostructures with a new morphology is more than that in microstructures. The antibacterial activity of Alq nanostructures was attributed to their more surface interactions with the bacterial cell wall. The molecules of 8-hydroxyquinoline in the Alq structure could play crucial roles in its antibacterial activity. To apply the achieved results, Alq was incorporated with polystyrene (PS) in a ratio of 2% to fabricate a PS/Alq composite and used to coat glass beakers, which showed inhibition in the bacterial growth reduced to 65% compared with non-coated beakers. The finding of this study showed that Alq could be used as a promising antimicrobial coating.

References

Khan A, Huang K, Jinzhong Z, Zhu T, Morsi Y, Aldalbahi A . Exploration of the antibacterial and wound healing potential of a PLGA/silk fibroin based electrospun membrane loaded with zinc oxide nanoparticles. J Mater Chem B. 2021; 9(5):1452-1465. DOI: 10.1039/d0tb02822c. View

Burrows H, Fernandes M, Seixas de Melo J, Monkman A, Navaratnam S . Characterization of the triplet state of tris(8-hydroxyquinoline)aluminium(III) in benzene solution. J Am Chem Soc. 2003; 125(50):15310-1. DOI: 10.1021/ja037254f. View

Back S, Park J, Cui C, Ahn D . Bio-recognitive photonics of a DNA-guided organic semiconductor. Nat Commun. 2016; 7:10234. PMC: 4725759. DOI: 10.1038/ncomms10234. View

Yin C, Wang Z, Ding X, Chen X, Wang J, Yang E . Crystalline ruthenium polypyridine nanoparticles: a targeted treatment of bacterial infection with multifunctional antibacterial, adhesion and surface-anchoring photosensitizer properties. J Mater Chem B. 2021; 9(18):3808-3825. DOI: 10.1039/d1tb00103e. View

Paolino M, Brindisi M, Vallone A, Butini S, Campiani G, Nannicini C . Development of Potent Inhibitors of the Mycobacterium tuberculosis Virulence Factor Zmp1 and Evaluation of Their Effect on Mycobacterial Survival inside Macrophages. ChemMedChem. 2018; 13(5):422-430. DOI: 10.1002/cmdc.201700759. View

Joaquim A, Gionbelli M, Gosmann G, Fuentefria A, Lopes M, de Andrade S . Novel Antimicrobial 8-Hydroxyquinoline-Based Agents: Current Development, Structure-Activity Relationships, and Perspectives. J Med Chem. 2021; 64(22):16349-16379. DOI: 10.1021/acs.jmedchem.1c01318. View

Altaf M, Zeyad M, Hashmi M, Manoharadas S, Althaf Hussain S, Ali Abuhasil M . Effective inhibition and eradication of pathogenic biofilms by titanium dioxide nanoparticles synthesized using extract. RSC Adv. 2022; 11(31):19248-19257. PMC: 9033554. DOI: 10.1039/d1ra02876f. View

Jianbo H, Tingting Z, Yongjing C, Yuanyuan Z, Weiqing Y, Menglin M . Study on Relationship Between Fluorescence Properties and Structure of Substituted 8-Hydroxyquinoline Zinc Complexes. J Fluoresc. 2018; 28(5):1121-1126. DOI: 10.1007/s10895-018-2275-7. View

Rautenbach M, Gerstner G, Vlok N, Kulenkampff J, Westerhoff H . Analyses of dose-response curves to compare the antimicrobial activity of model cationic alpha-helical peptides highlights the necessity for a minimum of two activity parameters. Anal Biochem. 2006; 350(1):81-90. DOI: 10.1016/j.ab.2005.11.027. View

10.

Maruthupandy M, Seo J . Allyl isothiocyanate encapsulated halloysite covered with polyacrylate as a potential antibacterial agent against food spoilage bacteria. Mater Sci Eng C Mater Biol Appl. 2019; 105:110016. DOI: 10.1016/j.msec.2019.110016. View

11.

Soliman S, Sanad M, Shalan A . Synthesis, characterization and antimicrobial activity applications of grafted copolymer alginate--poly(-vinyl imidazole). RSC Adv. 2022; 11(19):11541-11548. PMC: 8695916. DOI: 10.1039/d1ra01874d. View

12.

Fraser R, Creanor J . The mechanism of inhibition of ribonucleic acid synthesis by 8-hydroxyquinoline and the antibiotic lomofungin. Biochem J. 1975; 147(3):401-10. PMC: 1165465. DOI: 10.1042/bj1470401. View

13.

Eivazzadeh-Keihan R, Aliabadi H, Radinekiyan F, Sobhani M, Farzane Khalili , Maleki A . Investigation of the biological activity, mechanical properties and wound healing application of a novel scaffold based on lignin-agarose hydrogel and silk fibroin embedded zinc chromite nanoparticles. RSC Adv. 2022; 11(29):17914-17923. PMC: 9033182. DOI: 10.1039/d1ra01300a. View

14.

Lei X, Wang J, Chen J, Gao J, Zhang J, Zhao Q . The in vitro evaluation of antibacterial efficacy optimized with cellular apoptosis on multi-functional polyurethane sealers for the root canal treatment. J Mater Chem B. 2021; 9(5):1370-1383. DOI: 10.1039/d0tb02504f. View

15.

Qais F, Ahmad I, Altaf M, Manoharadas S, Al-Rayes B, Ali Abuhasil M . Biofabricated silver nanoparticles exhibit broad-spectrum antibiofilm and antiquorum sensing activity against Gram-negative bacteria. RSC Adv. 2022; 11(23):13700-13710. PMC: 8697519. DOI: 10.1039/d1ra00488c. View

16.

Elshikh M, Ahmed S, Funston S, Dunlop P, McGaw M, Marchant R . Resazurin-based 96-well plate microdilution method for the determination of minimum inhibitory concentration of biosurfactants. Biotechnol Lett. 2016; 38(6):1015-9. PMC: 4853446. DOI: 10.1007/s10529-016-2079-2. View

17.

Mann E, Manna D, Mettetal M, May R, Dannemiller E, Chung K . Surface micropattern limits bacterial contamination. Antimicrob Resist Infect Control. 2014; 3:28. PMC: 4166016. DOI: 10.1186/2047-2994-3-28. View

18.

Wangtrakuldee P, Byrd M, Campos C, Henderson M, Zhang Z, Clare M . Discovery of Inhibitors of Methionine Aminopeptidase with Antibacterial Activity. ACS Med Chem Lett. 2013; 4(8). PMC: 3871185. DOI: 10.1021/ml400034m. View

19.

Manoharadas S, Altaf M, Alrefaei A, Devasia R, Badjah Hadj A, Ali Abuhasil M . Concerted dispersion of biofilm by bacteriophage and 'green synthesized' silver nanoparticles. RSC Adv. 2022; 11(3):1420-1429. PMC: 8693614. DOI: 10.1039/d0ra09725j. View

20.

Sun Q, Duan M, Fan W, Fan B . Ca-Si mesoporous nanoparticles with the optimal Ag-Zn ratio inhibit the infection of teeth through dentinal tubule infiltration: an and study. J Mater Chem B. 2021; 9(9):2200-2211. DOI: 10.1039/d0tb02704a. View