Role of HMGB1 in Vitiligo: Current Perceptions and Future Perspectives

Overview

Journal Clin Cosmet Investig Dermatol

Publisher Dove Medical Press

Specialty Dermatology

Date 2022 Oct 21

PMID 36267690

Authors

Guangmin Wei

Yinghao Pan

Jingying Wang

Xia Xiong

Yuanmin He

Jixiang Xu

Affiliations

Soon will be listed here.

Abstract

Vitiligo is a chronic depigmenting disorder of the skin and mucosa caused by the destruction of epidermal melanocytes. Although the exact mechanism has not been elucidated, studies have shown that oxidative stress plays an important role in the pathogenesis of vitiligo. High mobility group box protein B1 (HMGB1) is a major nonhistone protein and an extracellular proinflammatory or chemotactic molecule that is actively secreted or passively released by necrotic cells. Recent data showed that HMGB1 is overexpressed in both blood and lesional specimens from vitiligo patients. Moreover, oxidative stress triggers the release of HMGB1 from keratinocytes and melanocytes, indicating that HMGB1 may participate in the pathological process of vitiligo. Overall, this review mainly focuses on the role of HMGB1 in the potential mechanisms underlying vitiligo depigmentation under oxidative stress. In this review, we hope to provide new insights into vitiligo pathogenesis and treatment strategies.

Citing Articles

Etiopathogenesis and Emerging Methods for Treatment of Vitiligo.

Iwanowski T, Kolkowski K, Nowicki R, Sokolowska-Wojdylo M Int J Mol Sci. 2023; 24(11).

PMID: 37298700 PMC: 10253679. DOI: 10.3390/ijms24119749.

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