Quality of Life in Osteoporotic Patients

Overview

Journal Orthop Rev (Pavia)

Specialty Orthopedics

Date 2022 Oct 21

PMID 36267218

Authors

Maria Rizzo

Gisella Tammaro

Amedeo Guarino

Morena Basso

Andrea Cozzolino

Massimo Mariconda

Affiliations

Soon will be listed here.

Abstract

Background: Osteoporosis is responsible for fragility fractures, which are associated with impaired quality of life (QoL) and disability.

Objective: The aim of the study was to evaluate the QoL in patients affected by osteoporosis and possible determinants.

Methods: One-hundred thirty-four subjects followed at the osteoprosis outpatient clinic at our institution completed the QUALEFFO-41 questionnaire for quality of life. All subjects had undergone bone densitometry measurement and the FRAX index, summarizing the risk of fragility fracture, was calculated for each of them. The QoL in these subjects and its possible determinants were investigated with univariate and multiple linear regression analysis.

Results: Subjects with osteoporosis had lower scores in the domains of physical and social function of the QUALEFFO questionnaire in comparison with subjects with normal bome mineral density. Main factors associated with impairment in QoL were high FRAX score and body mass index (BMI).

Conclusion: Physical and social function is reduced in osteoporotic subjects. High BMI and an increased risk of fragility fracture were main determinants of impairment in the QoL in this study.

Citing Articles

Regular physical activity improves physical function and health-related quality of life among middle-aged and older women who suffered a fragility fracture-a population-based cohort.

Barcelos A, Lopes D, Mazeda C, Canhao H, da Cunha Branco J, Rodrigues A Osteoporos Int. 2024; 35(12):2203-2213.

PMID: 39392521 PMC: 11579055. DOI: 10.1007/s00198-024-07265-4.

Impacts of people at-risk of either cow milk allergies or lactose intolerance on their daily calcium intake and bone mineral density.

Kongpharm K, Nakklay P, Kongtong C, Tanapumchai P, Prapkree L, Rueangsri N Front Nutr. 2024; 11:1421275.

PMID: 39221165 PMC: 11362075. DOI: 10.3389/fnut.2024.1421275.

References

Hallberg I, Rosenqvist A, Kartous L, Lofman O, Wahlstrom O, Toss G . Health-related quality of life after osteoporotic fractures. Osteoporos Int. 2004; 15(10):834-41. DOI: 10.1007/s00198-004-1622-5. View

Mediati R, Vellucci R, Dodaro L . Pathogenesis and clinical aspects of pain in patients with osteoporosis. Clin Cases Miner Bone Metab. 2015; 11(3):169-72. PMC: 4269137. View

Pascarella R, Cerbasi S, Politano R, Balato G, Fantasia R, Orabona G . Surgical results and factors influencing outcome in patients with posterior wall acetabular fracture. Injury. 2017; 48(8):1819-1824. DOI: 10.1016/j.injury.2017.05.039. View

Lin J, Lane J . Osteoporosis: a review. Clin Orthop Relat Res. 2004; (425):126-34. View

Cummings S, Melton L . Epidemiology and outcomes of osteoporotic fractures. Lancet. 2002; 359(9319):1761-7. DOI: 10.1016/S0140-6736(02)08657-9. View

Kanis J, Johnell O, Oden A, De Laet C, Jonsson B, Dawson A . Ten-year risk of osteoporotic fracture and the effect of risk factors on screening strategies. Bone. 2002; 30(1):251-8. DOI: 10.1016/s8756-3282(01)00653-6. View

Romagnoli E, Carnevale V, Nofroni I, DErasmo E, Paglia F, De Geronimo S . Quality of life in ambulatory postmenopausal women: the impact of reduced bone mineral density and subclinical vertebral fractures. Osteoporos Int. 2004; 15(12):975-80. DOI: 10.1007/s00198-004-1633-2. View

Kanis J, Johnell O, Oden A, Jonsson B, De Laet C, Dawson A . Risk of hip fracture according to the World Health Organization criteria for osteopenia and osteoporosis. Bone. 2000; 27(5):585-90. DOI: 10.1016/s8756-3282(00)00381-1. View

Fassio A, Idolazzi L, Rossini M, Gatti D, Adami G, Giollo A . The obesity paradox and osteoporosis. Eat Weight Disord. 2018; 23(3):293-302. DOI: 10.1007/s40519-018-0505-2. View

10.

Gonzalez Silva Y, Abad Manteca L, de la Red Gallego H, Alvarez Munoz M, Rodriguez Carbajo M, Murcia Casado T . Relationship between the FRAX index and physical and cognitive functioning in older people. Ann Med. 2018; 50(6):538-543. DOI: 10.1080/07853890.2018.1505052. View

11.

Mariconda M, Costa G, Cerbasi S, Recano P, Orabona G, Gambacorta M . Factors Predicting Mobility and the Change in Activities of Daily Living After Hip Fracture: A 1-Year Prospective Cohort Study. J Orthop Trauma. 2016; 30(2):71-7. DOI: 10.1097/BOT.0000000000000448. View

12.

Lips P, Cooper C, Agnusdei D, Caulin F, Egger P, Johnell O . Quality of life in patients with vertebral fractures: validation of the Quality of Life Questionnaire of the European Foundation for Osteoporosis (QUALEFFO). Working Party for Quality of Life of the European Foundation for Osteoporosis. Osteoporos Int. 1999; 10(2):150-60. DOI: 10.1007/s001980050210. View

13.

Hubscher M, Vogt L, Schmidt K, Fink M, Banzer W . Perceived pain, fear of falling and physical function in women with osteoporosis. Gait Posture. 2010; 32(3):383-5. DOI: 10.1016/j.gaitpost.2010.06.018. View

14.

Kanis J . Assessment of fracture risk and its application to screening for postmenopausal osteoporosis: synopsis of a WHO report. WHO Study Group. Osteoporos Int. 1994; 4(6):368-81. DOI: 10.1007/BF01622200. View