Role of MicroRNAs in Trophoblast Invasion and Spiral Artery Remodeling: Implications for Preeclampsia

Overview

Journal Front Cell Dev Biol

Specialty Cell Biology

Date 2022 Oct 20

PMID 36263015

Authors

Heyam Hayder

Yanan Shan

Yan Chen

Jacob Anderson OBrien

Chun Peng

Affiliations

Soon will be listed here.

Abstract

It is now well-established that microRNAs (miRNAs) are important regulators of gene expression. The role of miRNAs in placental development and trophoblast function is constantly expanding. Trophoblast invasion and their ability to remodel uterine spiral arteries are essential for proper placental development and successful pregnancy outcome. Many miRNAs are reported to be dysregulated in pregnancy complications, especially preeclampsia and they exert various regulatory effects on trophoblasts. In this review, we provide a brief overview of miRNA biogenesis and their mechanism of action, as well as of trophoblasts differentiation, invasion and spiral artery remodeling. We then discuss the role of miRNAs in trophoblasts invasion and spiral artery remodeling, focusing on miRNAs that have been thoroughly investigated, especially using multiple model systems. We also discuss the potential role of miRNAs in the pathogenesis of preeclampsia.

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