Relationship Between Blood Pressure and Intraocular Pressure in the JPHC-NEXT Eye Study

Overview

Journal Sci Rep

Specialty Science

Date 2022 Oct 19

PMID 36261671

Authors

Tomoyo Yasukawa

Akiko Hanyuda

Kazumasa Yamagishi

Kenya Yuki

Miki Uchino

Yoko Ozawa

Mariko Sasaki

Kazuo Tsubota

Norie Sawada

Kazuno Negishi

Shoichiro Tsugane

Hiroyasu Iso

Affiliations

Soon will be listed here.

Abstract

Although a positive link between hypertension and intraocular pressure (IOP) has been suggested, the individual effects of systolic and diastolic blood pressure (SBP and DBP, respectively) on IOP remain unclear, particularly among Japanese populations. Here, we conducted a large-scale, cross-sectional study to determine individual and combined effects of SBP/DBP and hypertension on IOP. In total, 6783 Japanese people aged over 40 years underwent systemic and ophthalmological examinations, including measurements of blood pressure and IOP, conducted using non-contact tonometers. After adjusting for a priori known confounding factors, SBP and DBP levels were found to be positively correlated with IOP levels. The multivariable-adjusted odds ratio when comparing the hypertensive and normotensive groups for the prevalence of ocular hypertension was 1.88 (95% confidence interval, 1.14-3.08). When analysing the combined effects of SBP and DBP on ocular hypertension, SBP elevation had a greater effect on ocular hypertension than DBP increase. In conclusion, SBP and DBP levels and the prevalence of systemic hypertension were found to be positively associated with IOP levels and the prevalence of ocular hypertension in an ophthalmologically healthy Japanese population. Our findings suggest that systemic blood pressure control may be key for controlling IOP.

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References

. Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants. Lancet. 2021; 398(10304):957-980. PMC: 8446938. DOI: 10.1016/S0140-6736(21)01330-1. View

Kim Y, Jung S, Nam G, Do Han K, Bok A, Baek S . High intraocular pressure is associated with cardiometabolic risk factors in South Korean men: Korean National Health and Nutrition Examination Survey, 2008-2010. Eye (Lond). 2014; 28(6):672-9. PMC: 4058609. DOI: 10.1038/eye.2014.43. View

Leeman M, Kestelyn P . Glaucoma and Blood Pressure. Hypertension. 2019; 73(5):944-950. DOI: 10.1161/HYPERTENSIONAHA.118.11507. View

Flint A, Conell C, Ren X, Banki N, Chan S, Rao V . Effect of Systolic and Diastolic Blood Pressure on Cardiovascular Outcomes. N Engl J Med. 2019; 381(3):243-251. DOI: 10.1056/NEJMoa1803180. View

Tielsch J, Katz J, Sommer A, Quigley H, Javitt J . Hypertension, perfusion pressure, and primary open-angle glaucoma. A population-based assessment. Arch Ophthalmol. 1995; 113(2):216-21. DOI: 10.1001/archopht.1995.01100020100038. View

Seino Y, Nanjo K, Tajima N, Kadowaki T, Kashiwagi A, Araki E . Report of the committee on the classification and diagnostic criteria of diabetes mellitus. J Diabetes Investig. 2014; 1(5):212-28. PMC: 4020724. DOI: 10.1111/j.2040-1124.2010.00074.x. View

Morgan R, Drance S . Chronic open-angle glaucoma and ocular hypertension. An epidemiological study. Br J Ophthalmol. 1975; 59(4):211-5. PMC: 1042596. DOI: 10.1136/bjo.59.4.211. View

Leske M, Podgor M . Intraocular pressure, cardiovascular risk variables, and visual field defects. Am J Epidemiol. 1983; 118(2):280-7. DOI: 10.1093/oxfordjournals.aje.a113634. View

Gordon M, Beiser J, Brandt J, Heuer D, Higginbotham E, Johnson C . The Ocular Hypertension Treatment Study: baseline factors that predict the onset of primary open-angle glaucoma. Arch Ophthalmol. 2002; 120(6):714-20; discussion 829-30. DOI: 10.1001/archopht.120.6.714. View

10.

Quigley H, Broman A . The number of people with glaucoma worldwide in 2010 and 2020. Br J Ophthalmol. 2006; 90(3):262-7. PMC: 1856963. DOI: 10.1136/bjo.2005.081224. View

11.

Yamagami J, Araie M, Aihara M, Yamamoto S . Diurnal variation in intraocular pressure of normal-tension glaucoma eyes. Ophthalmology. 1993; 100(5):643-50. DOI: 10.1016/s0161-6420(93)31594-0. View

12.

Tomoyose E, Higa A, Sakai H, Sawaguchi S, Iwase A, Tomidokoro A . Intraocular pressure and related systemic and ocular biometric factors in a population-based study in Japan: the Kumejima study. Am J Ophthalmol. 2010; 150(2):279-86. DOI: 10.1016/j.ajo.2010.03.009. View

13.

Arora S, Roelofs K, Damji K . Tonometer tip disinfection: principles, evidence, and importance of end-user engagement in policy formulation. Can J Ophthalmol. 2013; 48(3):136-7. DOI: 10.1016/j.jcjo.2013.01.016. View

14.

Hennis A, Wu S, Nemesure B, Leske M . Hypertension, diabetes, and longitudinal changes in intraocular pressure. Ophthalmology. 2003; 110(5):908-14. DOI: 10.1016/S0161-6420(03)00075-7. View

15.

Mitchell P, Lee A, Wang J, Rochtchina E . Intraocular pressure over the clinical range of blood pressure: blue mountains eye study findings. Am J Ophthalmol. 2005; 140(1):131-2. DOI: 10.1016/j.ajo.2004.12.088. View

16.

Shin H, Subrayan V, Tajunisah I . Changes in anterior chamber depth and intraocular pressure after phacoemulsification in eyes with occludable angles. J Cataract Refract Surg. 2010; 36(8):1289-95. DOI: 10.1016/j.jcrs.2010.02.024. View

17.

Fantin F, Giani A, Zoico E, Rossi A, Mazzali G, Zamboni M . Weight Loss and Hypertension in Obese Subjects. Nutrients. 2019; 11(7). PMC: 6682923. DOI: 10.3390/nu11071667. View

18.

Imai K, Hamaguchi M, Mori K, Takeda N, Fukui M, Kato T . Metabolic syndrome as a risk factor for high-ocular tension. Int J Obes (Lond). 2010; 34(7):1209-17. DOI: 10.1038/ijo.2010.32. View

19.

McLeod S, West S, Quigley H, Fozard J . A longitudinal study of the relationship between intraocular and blood pressures. Invest Ophthalmol Vis Sci. 1990; 31(11):2361-6. View

20.

Quigley H . Glaucoma. Lancet. 2011; 377(9774):1367-77. DOI: 10.1016/S0140-6736(10)61423-7. View