A Case of Death of Patient with Ovarian Fibroma Combined with Meigs Syndrome and Literature Review

Overview

Journal Diagn Pathol

Publisher Biomed Central

Specialty Pathology

Date 2022 Oct 17

PMID 36253781

Authors

Na Tan

Kai-Yuan Jin

Xiao-Rong Yang

Cheng-Fang Li

Jin Yao

Hong Zheng

Affiliations

Soon will be listed here.

Abstract

Ovarian fibroma is the most common benign pure stromal tumor. It has no specific clinical manifestation, most of which are pelvic or adnexal masses. 10-15% of cases with hydrothorax or ascites, after tumor resection, hydrothorax and ascites disappear, known as Meigs Syndrome. The elevated level of CA125 in a few patients was easily misdiagnosed as ovarian malignant tumor. A case of bilateral Ovarian fibroma associated with Meigs Syndrome is reported and the literature is reviewed in order to improve the understanding of the changes and avoid misdiagnosis.

Citing Articles

Meigs' syndrome with elevated CA-125 and HE-4: a case report and literature review.

Seong J, Ravshan A, Narkhodzha S, Saida K, Jamshid A, Bahriddin B Front Med (Lausanne). 2025; 12:1533388.

PMID: 40066164 PMC: 11891057. DOI: 10.3389/fmed.2025.1533388.

Krukenberg tumor arising from gastric cancer presenting as Pseudo-Meigs' syndrome: a case report and literature review.

Qiu S, Jiang H, Ding H, Feng L Front Med (Lausanne). 2024; 11:1427568.

PMID: 39346945 PMC: 11427251. DOI: 10.3389/fmed.2024.1427568.

Meigs syndrome presenting with recurrent unilateral pleural effusion.

Ng B, Johari How S, Abeed N, Low H, Osman R, Yu-Lin A Respirol Case Rep. 2024; 12(7):e01421.

PMID: 38938762 PMC: 11208080. DOI: 10.1002/rcr2.1421.

Mucin-Producing Lobular Breast Carcinoma Metastasis to an Ovarian Fibroma: Histopathological and Immunohistochemical Analysis of a Rare Case and Literature Review.

Faur A, Gurban C, Daescu E, Tirziu R, Lazar D, Ghenciu L Diagnostics (Basel). 2024; 14(9).

PMID: 38732367 PMC: 11083407. DOI: 10.3390/diagnostics14090953.

Surgical Treatment of a Rare Case of Ovarian Fibroma Associated With Elevated CA125 Levels in a Patient of Reproductive Age: A Case Report.

Thanasa A, Thanasa E, Kamaretsos E, Paraoulakis I, Ziogas A, Kontogeorgis G Cureus. 2023; 15(1):e34097.

PMID: 36843723 PMC: 9946278. DOI: 10.7759/cureus.34097.

References

Nemeth A, Patel S . Meigs syndrome revisited. J Thorac Imaging. 2003; 18(2):100-3. DOI: 10.1097/00005382-200304000-00009. View

Chung B, Park S, Lee J, Park H, Kim Y, Oh Y . Magnetic resonance imaging features of ovarian fibroma, fibrothecoma, and thecoma. Abdom Imaging. 2014; 40(5):1263-72. DOI: 10.1007/s00261-014-0257-z. View

Chen Y, Hsieh C, Eng H, Huang C . Ovarian fibroma in a 7-month-old infant: a case report and review of the literature. Pediatr Surg Int. 2004; 20(11-12):894-7. DOI: 10.1007/s00383-004-1284-6. View

Zhang Z, Wu Y, Gao J . CT diagnosis in the thecoma-fibroma group of the ovarian stromal tumors. Cell Biochem Biophys. 2014; 71(2):937-43. DOI: 10.1007/s12013-014-0288-7. View

Hogan M, Andreotti R . Ovarian Fibroma Presenting With Meigs Syndrome. Ultrasound Q. 2015; 31(3):215-8. DOI: 10.1097/RUQ.0000000000000144. View