Prospective Metabolomic Studies in Precision Medicine: The AKRIBEA Project

Overview

Journal Handb Exp Pharmacol

Specialty Pharmacology

Date 2022 Oct 17

PMID 36253553

Authors

Maider Bizkarguenaga

Ruben Gil-Redondo

Chiara Bruzzone

Ganeko Bernardo-Seisdedos

Ana Lain

Beatriz Gonzalez-Valle

Nieves Embade

Jose M Mato

Oscar Millet

Affiliations

Soon will be listed here.

Abstract

For a long time, conventional medicine has analysed biomolecules to diagnose diseases. Yet, this approach has proven valid only for a limited number of metabolites and often through a bijective relationship with the disease (i.e. glucose relationship with diabetes), ultimately offering incomplete diagnostic value. Nowadays, precision medicine emerges as an option to improve the prevention and/or treatment of numerous pathologies, focusing on the molecular mechanisms, acting in a patient-specific dimension, and leveraging multiple contributing factors such as genetic, environmental, or lifestyle. Metabolomics grasps the required subcellular complexity while being sensitive to all these factors, which results in a most suitable technique for precision medicine. The aim of this chapter is to describe how NMR-based metabolomics can be integrated in the design of a precision medicine strategy, using the Precision Medicine Initiative of the Basque Country (the AKRIBEA project) as a case study. To that end, we will illustrate the procedures to be followed when conducting an NMR-based metabolomics study with a large cohort of individuals, emphasizing the critical points. The chapter will conclude with the discussion of some relevant biomedical applications.

Citing Articles

MetSCORE: a molecular metric to evaluate the risk of metabolic syndrome based on serum NMR metabolomics.

Gil-Redondo R, Conde R, Bruzzone C, Seco M, Bizkarguenaga M, Gonzalez-Valle B Cardiovasc Diabetol. 2024; 23(1):272.

PMID: 39048982 PMC: 11271192. DOI: 10.1186/s12933-024-02363-3.

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