Congenital Herpes Simplex Virus: A Histopathological View of the Placenta

Overview

Journal Cureus

Specialty Biomedical Engineering

Date 2022 Oct 17

PMID 36249599

Authors

Theodora-Eleftheria Deftereou

Anna Trypidi

Christina Angelika Alexiadi

Paschalis Theotokis

Maria Eleni Manthou

Soultana Meditskou

Maria Simopoulou

Maria Lambropoulou

Affiliations

Soon will be listed here.

Abstract

Congenital Herpes simplex virus (HSV) infection is considered a common pregnancy pathology that is not always easy to diagnose. This study aimed to present the spectrum of placental histopathological lesions in pregnancies complicated by HSV infection. MEDLINE and Google Scholar databases were searched using the keywords "HSV" and "placental histopathology" up to June 20, 2022. Study inclusion required presenting placental histopathological anomalies in pregnant women diagnosed with HSV infection antenatally, during labor, or postnatally. Herein, we briefly present placental pathogenesis conditions, which have been correlated with congenital HSV infection, providing clinicians with a short review describing herpetic placental pathology.

Citing Articles

Gabrielli L, Pavoni M, Monari F, Baiesi Pillastrini F, Bonasoni M, Locatelli C Microorganisms. 2025; 13(1).

PMID: 39858839 PMC: 11767843. DOI: 10.3390/microorganisms13010071.

Roles of TGF-β1 in Viral Infection during Pregnancy: Research Update and Perspectives.

Trinh Q, Pham N, Takada K, Ushijima H, Komine-Aizawa S, Hayakawa S Int J Mol Sci. 2023; 24(7).

PMID: 37047462 PMC: 10095195. DOI: 10.3390/ijms24076489.

Archaic connectivity between the sulfated heparan sulfate and the herpesviruses - An evolutionary potential for cross-species interactions.

Elste J, Chan A, Patil C, Tripathi V, Shadrack D, Jaishankar D Comput Struct Biotechnol J. 2023; 21:1030-1040.

PMID: 36733705 PMC: 9880898. DOI: 10.1016/j.csbj.2023.01.005.

References

Wang W, Zhang M, Gong L, Wu Q . Necrotizing funisitis and calcification of umbilical vein: case report and review. BMC Pregnancy Childbirth. 2021; 21(1):296. PMC: 8042875. DOI: 10.1186/s12884-021-03743-3. View

Raspollini M, Oliva E, Roberts D . Placental histopathologic features in patients with thrombophilic mutations. J Matern Fetal Neonatal Med. 2007; 20(2):113-23. DOI: 10.1080/14767050601178345. View

Fa F, Laup L, Mandelbrot L, Sibiude J, Picone O . Fetal and neonatal abnormalities due to congenital herpes simplex virus infection: a literature review. Prenat Diagn. 2019; 40(4):408-414. DOI: 10.1002/pd.5587. View

Vasileiadis G, Roukema H, Romano W, Walton J, Gagnon R . Intrauterine herpes simplex infection. Am J Perinatol. 2003; 20(2):55-8. DOI: 10.1055/s-2003-38319. View

Bittencourt A, Garcia A . The placenta in hematogenous infections. Pediatr Pathol Mol Med. 2002; 21(4):401-32. DOI: 10.1080/152279502760157768. View

Jaiman S, Romero R, Pacora P, Jung E, Bhatti G, Yeo L . Disorders of placental villous maturation in fetal death. J Perinat Med. 2020; . PMC: 8262362. DOI: 10.1515/jpm-2020-0030. View

Jablonska A, Studzinska M, Suski P, Kalinka J, Paradowska E . Enhanced expression of IFI16 and RIG-I in human third-trimester placentas following HSV-1 infection. Clin Exp Immunol. 2018; 193(2):255-263. PMC: 6046492. DOI: 10.1111/cei.13143. View

Chan J . Villitis of Unknown Etiology and Massive Chronic Intervillositis. Surg Pathol Clin. 2016; 6(1):115-26. DOI: 10.1016/j.path.2012.11.004. View

Matsika A . Clinical correlates of histopathological entities of the placenta. Aust J Gen Pract. 2021; 50(1-2):62-69. DOI: 10.31128/AJGP-11-19-5154. View

10.

Zaga-Clavellina V, Diaz L, Olmos-Ortiz A, Godinez-Rubi M, Rojas-Mayorquin A, Ortuno-Sahagun D . Central role of the placenta during viral infection: Immuno-competences and miRNA defensive responses. Biochim Biophys Acta Mol Basis Dis. 2021; 1867(10):166182. DOI: 10.1016/j.bbadis.2021.166182. View

11.

Freitag L, von Kaisenberg C, Kreipe H, Hussein K . Expression analysis of leukocytes attracting cytokines in chronic histiocytic intervillositis of the placenta. Int J Clin Exp Pathol. 2013; 6(6):1103-11. PMC: 3657363. View

12.

Amidzic J, Vuckovic N, capo I, Levakov A . Congenital cytomegalic inclusion disease with disseminated Herpes simplex infection. Malays J Pathol. 2019; 41(1):75-78. View

13.

Chatterjee A, Chartrand S, Harrison C, Bewtra C . Severe intrauterine herpes simplex disease with placentitis in a newborn of a mother with recurrent genital infection at delivery. J Perinatol. 2002; 21(8):559-64. DOI: 10.1038/sj.jp.7210573. View

14.

Kinoshita T, Hatanaka A, Mori J, Akaiwa K, Imaizumi H . Multimodal Imaging of a Severe Case of Neonatal Acute Retinal Necrosis and Lens Vacuoles Associated with Herpes Simplex Virus Infection. Ocul Immunol Inflamm. 2021; 30(4):1009-1015. DOI: 10.1080/09273948.2020.1841803. View

15.

Bedolla G, Stanek J . Intrauterine hematogenous herpetic infection. Arch Pathol Lab Med. 2004; 128(10):1189-90. DOI: 10.5858/2004-128-1189-IHHI. View

16.

Syridou G, Spanakis N, Konstantinidou A, Piperaki E, Kafetzis D, Patsouris E . Detection of cytomegalovirus, parvovirus B19 and herpes simplex viruses in cases of intrauterine fetal death: association with pathological findings. J Med Virol. 2008; 80(10):1776-82. DOI: 10.1002/jmv.21293. View

17.

Heerema-McKenney A . Defense and infection of the human placenta. APMIS. 2018; 126(7):570-588. DOI: 10.1111/apm.12847. View

18.

ROBB J, Benirschke K, Mannino F, Voland J . Intrauterine latent herpes simplex virus infection: II. Latent neonatal infection. Hum Pathol. 1986; 17(12):1210-7. DOI: 10.1016/s0046-8177(86)80562-7. View

19.

Magli M, Jones G, Lundin K, Van den Abbeel E . Atlas of human embryology: from oocytes to preimplantation embryos. Preface. Hum Reprod. 2012; 27 Suppl 1:i1. DOI: 10.1093/humrep/des229. View

20.

Megli C, Coyne C . Infections at the maternal-fetal interface: an overview of pathogenesis and defence. Nat Rev Microbiol. 2021; 20(2):67-82. PMC: 8386341. DOI: 10.1038/s41579-021-00610-y. View