Association of Preconception Mixtures of Phenol and Phthalate Metabolites with Birthweight Among Subfertile Couples

Overview

Journal Environ Epidemiol

Publisher Wolters Kluwer

Specialty Environmental Health

Date 2022 Oct 17

PMID 36249269

Authors

Yu Zhang

Vicente Mustieles

Paige L Williams

Irene Souter

Antonia M Calafat

Melina Demokritou

Alexandria Lee

Stylianos Vagios

Russ Hauser

Carmen Messerlian

Affiliations

Soon will be listed here.

Abstract

Methods: We included 384 mothers and 211 fathers (203 couples) who gave birth to 384 singletons from a prospective cohort of couples seeking fertility evaluation. Urinary concentrations of bisphenol A (BPA), parabens, and 11 phthalate metabolites including those of di(2-ethylhexyl) phthalate (DEHP) were examined. Birthweight was abstracted from delivery records. We used principal component analysis and Bayesian Kernel Machine Regression (BKMR) to examine maternal and paternal preconception mixtures in relation to singleton birthweight. We also fit couple-based BKMR with hierarchical variable selection to assess couples' joint mixtures in relation to birthweight.

Results: PC scores of maternal and paternal preconception low molecular weight phthalates factor, and paternal preconception DEHP-BPA factor were associated with reduced birthweight. In BKMR models, we found that maternal preconception monoethyl phthalate and BPA concentrations, and paternal preconception mono-n-butyl phthalate concentrations were inversely associated with birthweight when the remaining mixture components were held at their median concentrations. In couple-based BKMR models, paternal preconception biomarkers contributed more to couples' joint effect on birthweight compared with maternal preconception biomarkers. A decreasing trend of birthweight was observed across quantiles of maternal, paternal, and couples' total preconception mixture concentrations, respectively.

Conclusions: Results from this preconception cohort of subfertile couples suggest a complex interplay between paternal and maternal preconception exposure to mixtures of nonpersistent chemicals, with both parental windows of exposure jointly contributing to reduced birthweight.

Citing Articles

Exposure to phthalate metabolites, bisphenol A, and psychosocial stress mixtures and pregnancy outcomes in the Atlanta African American maternal-child cohort.

Eatman J, Dunlop A, Barr D, Corwin E, Hill C, Brennan P Environ Res. 2023; 233:116464.

PMID: 37343758 PMC: 10527701. DOI: 10.1016/j.envres.2023.116464.

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