The Role of Hepatocyte Nuclear Factor 4α (HNF4α) in tumorigenesis
Overview
Affiliations
Hepatocyte Nuclear Factor 4 Alpha (HNF4α) is a master transcription factor mainly expressed in the liver, kidney, intestine and endocrine pancreas. It regulates multiple target genes involved in embryonic development and metabolism. HNF4α-related diseases include non-alcoholic fatty liver disease (NAFLD), obesity, hypertension, hyperlipidemia, metabolic syndrome and diabetes mellitus. Recently, HNF4α has been emerging as a key player in a variety of cancers. In this review, we summarized the role and mechanism of HNF4α in different types of cancers, especially in liver and colorectal cancer, aiming to provide additional guidance for intervention of these diseases.
A case of multiple bone metastases during the course of non-invasive bladder and prostate cancer.
Matsubara K, Hayakawa N, Kubota Y, Ohike N, Sunakawa Y, Koike J IJU Case Rep. 2025; 8(2):158-161.
PMID: 40034910 PMC: 11872209. DOI: 10.1002/iju5.12836.
Logan R, Shelton M, Horan N, Xue X, Maturin L, Eacret D Res Sq. 2024; .
PMID: 39399686 PMC: 11469374. DOI: 10.21203/rs.3.rs-5006061/v1.
Fatema K, Haidar Z, Tanim M, Nath S, Sajib A Toxicol Res. 2024; 40(4):653-672.
PMID: 39345741 PMC: 11436564. DOI: 10.1007/s43188-024-00255-y.
Dissecting the -regulatory syntax of transcription initiation with deep learning.
Cochran K, Yin M, Mantripragada A, Schreiber J, Marinov G, Shah S bioRxiv. 2024; .
PMID: 38853896 PMC: 11160661. DOI: 10.1101/2024.05.28.596138.
TSCRE: a comprehensive database for tumor-specific -regulatory elements.
Peng G, Liu B, Zheng M, Zhang L, Li H, Liu M NAR Cancer. 2024; 6(1):zcad063.
PMID: 38213995 PMC: 10782923. DOI: 10.1093/narcan/zcad063.