The Function of Omega-3 Polyunsaturated Fatty Acids in Response to Cadmium Exposure

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2022 Oct 17

PMID 36248838

Authors

Zhi Chen

Qinyue Lu

Jiacheng Wang

Xiang Cao

Kun Wang

Yuhao Wang

Yanni Wu

Zhangping Yang

Affiliations

Soon will be listed here.

Abstract

Throughout history, pollution has become a part of our daily life with the improvement of life quality and the advancement of industry and heavy industry. In recent years, the adverse effects of heavy metals, such as cadmium (Cd), on human health have been widely discussed, particularly on the immune system. Here, this review summarizes the available evidence on how Cd exposure may affect health. By analyzing the general manifestations of inflammation caused by Cd exposure, we find that the role of omega-3 (n-3) polyunsaturated fatty acids (PUFAs) can counteract Cd-induced harm. Additionally, we elucidate the effects of n-3 PUFAs on the immune system, and analyze their prophylactic and therapeutic effects on Cd exposure. Overall, this review highlights the role of n-3 PUFAs in the pathological changes induced by Cd exposure. Although n-3 PUFAs remain to be verified whether they can be used as therapeutic agents, as rehabilitation therapy, supplementation with n-3 PUFAs is reliable and effective.

Citing Articles

Association of Exposure to Heavy Metal Mixtures with Systemic Immune-Inflammation Index Among US Adults in NHANES 2011-2016.

Sun X, Deng Y, Fang L, Ni M, Wang X, Zhang T Biol Trace Elem Res. 2023; 202(7):3005-3017.

PMID: 37817047 DOI: 10.1007/s12011-023-03901-y.

Omega-3 Polyunsaturated Fatty Acids Alleviate Intestinal Barrier Dysfunction in Obstructive Jaundice Rats.

Zhang C, Yin Z, Hu F, Lin X, Guan Q, Zhang F Mol Biotechnol. 2023; 66(8):1954-1960.

PMID: 37507597 DOI: 10.1007/s12033-023-00829-5.

References

Djordjevic V, Wallace D, Schweitzer A, Boricic N, Knezevic D, Matic S . Environmental cadmium exposure and pancreatic cancer: Evidence from case control, animal and in vitro studies. Environ Int. 2019; 128:353-361. DOI: 10.1016/j.envint.2019.04.048. View

Dentin R, Benhamed F, Pegorier J, Foufelle F, Viollet B, Vaulont S . Polyunsaturated fatty acids suppress glycolytic and lipogenic genes through the inhibition of ChREBP nuclear protein translocation. J Clin Invest. 2005; 115(10):2843-54. PMC: 1224299. DOI: 10.1172/JCI25256. View

Serhan C . Pro-resolving lipid mediators are leads for resolution physiology. Nature. 2014; 510(7503):92-101. PMC: 4263681. DOI: 10.1038/nature13479. View

Teague H, Harris M, Fenton J, Lallemand P, Shewchuk B, Shaikh S . Eicosapentaenoic and docosahexaenoic acid ethyl esters differentially enhance B-cell activity in murine obesity. J Lipid Res. 2014; 55(7):1420-33. PMC: 4076074. DOI: 10.1194/jlr.M049809. View

Ciesielski T, Williams S . Low Omega-3 intake is associated with high rates of depression and preterm birth on the country level. Sci Rep. 2020; 10(1):19749. PMC: 7661496. DOI: 10.1038/s41598-020-76552-x. View

Alshehri A, El-Kott A, El-Kenawy A, Khalifa H, AlRamlawy A . Cadmium chloride induces non-alcoholic fatty liver disease in rats by stimulating miR-34a/SIRT1/FXR/p53 axis. Sci Total Environ. 2021; 784:147182. DOI: 10.1016/j.scitotenv.2021.147182. View

Mackay I, Ford I, Thies F, Fielding S, Bachoo P, Brittenden J . Effect of Omega-3 fatty acid supplementation on markers of platelet and endothelial function in patients with peripheral arterial disease. Atherosclerosis. 2012; 221(2):514-20. DOI: 10.1016/j.atherosclerosis.2011.12.041. View

Zhang L, Jia N, Yang R, Wang F . Eicosapentaenoic acid reduces inflammation and apoptosis by SREBP1/TLR4/MYD88. Bratisl Lek Listy. 2020; 121(11):822-829. DOI: 10.4149/BLL_2020_135. View

Cho E, Park Y . Association between serum fatty acid composition and innate immune markers in healthy adults. Nutr Res Pract. 2016; 10(2):182-7. PMC: 4819129. DOI: 10.4162/nrp.2016.10.2.182. View

10.

Arteaga-Silva M, Arenas-Rios E, Bonilla-Jaime H, Damian-Matzumura P, Limon-Morales O, Hernandez-Rodriguez J . Neuroendocrine effects of cadmium exposure on male reproductive functions. Front Biosci (Landmark Ed). 2020; 26(2):286-326. DOI: 10.2741/4895. View

11.

Lv Q, He Q, Wu Y, Chen X, Ning Y, Chen Y . Investigating the Bioaccessibility and Bioavailability of Cadmium in a Cooked Rice Food Matrix by Using an 11-Day Rapid Caco-2/HT-29 Co-culture Cell Model Combined with an In Vitro Digestion Model. Biol Trace Elem Res. 2018; 190(2):336-348. DOI: 10.1007/s12011-018-1554-0. View

12.

Van Name M, Savoye M, Chick J, Galuppo B, Feldstein A, Pierpont B . A Low ω-6 to ω-3 PUFA Ratio (n-6:n-3 PUFA) Diet to Treat Fatty Liver Disease in Obese Youth. J Nutr. 2020; 150(9):2314-2321. PMC: 7467848. DOI: 10.1093/jn/nxaa183. View

13.

Taha A, Sharifpanah F, Wartenberg M, Sauer H . Omega-3 and Omega-6 polyunsaturated fatty acids stimulate vascular differentiation of mouse embryonic stem cells. J Cell Physiol. 2020; 235(10):7094-7106. DOI: 10.1002/jcp.29606. View

14.

Yang W, Vuong A, Xie C, Dietrich K, Karagas M, Lanphear B . Maternal cadmium exposure and neurobehavior in children: The HOME study. Environ Res. 2020; 186:109583. PMC: 7368093. DOI: 10.1016/j.envres.2020.109583. View

15.

Attaman J, Stanic A, Kim M, Lynch M, Rueda B, Styer A . The anti-inflammatory impact of omega-3 polyunsaturated Fatty acids during the establishment of endometriosis-like lesions. Am J Reprod Immunol. 2014; 72(4):392-402. DOI: 10.1111/aji.12276. View

16.

Howlett N, Avery S . Relationship between cadmium sensitivity and degree of plasma membrane fatty acid unsaturation in Saccharomyces cerevisiae. Appl Microbiol Biotechnol. 1997; 48(4):539-45. DOI: 10.1007/s002530051093. View

17.

Tsentsevitsky A, Zakyrjanova G, Petrov A . Cadmium desynchronizes neurotransmitter release in the neuromuscular junction: Key role of ROS. Free Radic Biol Med. 2020; 155:19-28. DOI: 10.1016/j.freeradbiomed.2020.05.017. View

18.

Genchi G, Sinicropi M, Lauria G, Carocci A, Catalano A . The Effects of Cadmium Toxicity. Int J Environ Res Public Health. 2020; 17(11). PMC: 7312803. DOI: 10.3390/ijerph17113782. View

19.

Farjadian S, Moghtaderi M, Kalani M, Gholami T, Teshnizi S . Effects of omega-3 fatty acids on serum levels of T-helper cytokines in children with asthma. Cytokine. 2016; 85:61-6. DOI: 10.1016/j.cyto.2016.06.002. View

20.

Liang P, Henning S, Grogan T, Elashoff D, Ye H, Cohen P . Effects of dietary omega-3 fatty acids on orthotopic prostate cancer progression, tumor associated macrophages, angiogenesis and T-cell activation-dependence on GPR120. Prostate Cancer Prostatic Dis. 2022; 25(3):539-546. PMC: 9308823. DOI: 10.1038/s41391-021-00440-2. View