The Clinicopathologic Features of 22 Cases With Primary Invasive Papillary Carcinoma of the Breast Identified in 1153 Cases With Invasive Breast Carcinoma: Single-Center Experience

Overview

Journal Eur J Breast Health

Publisher Galenos Publishing House

Date 2022 Oct 17

PMID 36248758

Authors

Canan Kelten Talu

Begum Yeni Erdem

Esra Arslan

Mehmet Ali Nazli

Yasemin Cakir

Didem Can Trabulus

Affiliations

Soon will be listed here.

Abstract

Objective: Invasive papillary carcinoma (IPC) of the breast is an uncommon histologic subtype with limited data in the literature. The aim of this study was to increase the evidence base by presenting clinicopathological findings of cases diagnosed as IPC.

Materials And Methods: Hematoxylin and eosin sections and immunostaining of surgical excision specimens diagnosed as invasive breast carcinoma were re-evaluated, retrospectively.

Results: IPC was detected in 22 cases (1.9%), of which 7 (0.6%) had pure and 15 (1.3%) had mixed morphology. Histologic types accompanying IPC were: Invasive ductal carcinoma (IDC) (15/15); invasive micropapillary carcinoma (3/15); and pleomorphic lobular carcinoma (1/15). Patient ages ranged between 36 and 89 (median 56.5) and the tumor size from 8 to 70 mm (median 19 mm). The histologic grade was 3 in five cases, 2 in 13, and 1 in four cases. The nuclear grade was 3 in 10 cases and 2 in 12. The values of positivity for estrogen receptor, progesterone receptor, human epidermal growth factor receptor-2, and Ki-67 index indicated Luminal B phenotype in 16 (72.7%), triple-negative in 5 (22.7%), and Luminal A in 1 case (4.6%). Ductal carcinoma was noted in 19 cases (86.4%).

Conclusion: IPC was mostly detected as an accompanying carcinoma to IDC at postmenopausal ages and was mostly Luminal B phenotype with intermediate-to-high grade features.

Citing Articles

Invasive papillary carcinoma of the breast.

Wang S, Zhang Q, Mao X Front Oncol. 2024; 14:1374091.

PMID: 38601769 PMC: 11004302. DOI: 10.3389/fonc.2024.1374091.

References

Zhong E, Cheng E, Goldfischer M, Hoda S . Papillary Lesions of the Male Breast: A Study of 117 Cases and Brief Review of the Literature Demonstrate a Broad Clinicopathologic Spectrum. Am J Surg Pathol. 2019; 44(1):68-76. DOI: 10.1097/PAS.0000000000001340. View

Tsang J, Ni Y, Chan S, Shao M, Law B, Tan P . Androgen receptor expression shows distinctive significance in ER positive and negative breast cancers. Ann Surg Oncol. 2014; 21(7):2218-28. DOI: 10.1245/s10434-014-3629-2. View

Vural O, Alnak A, Altundag K . Invasive papillary carcinoma of the breast: an overview of twenty-four cases. Am Surg. 2012; 78(3):E144-5. View

Kulka J, Madaras L, Floris G, Lax S . Papillary lesions of the breast. Virchows Arch. 2021; 480(1):65-84. PMC: 8983543. DOI: 10.1007/s00428-021-03182-7. View

Rakha E, Ellis I . Diagnostic challenges in papillary lesions of the breast. Pathology. 2017; 50(1):100-110. DOI: 10.1016/j.pathol.2017.10.005. View

Fisher E, Palekar A, Redmond C, Barton B, Fisher B . Pathologic findings from the National Surgical Adjuvant Breast Project (protocol no. 4). VI. Invasive papillary cancer. Am J Clin Pathol. 1980; 73(3):313-22. DOI: 10.1093/ajcp/73.3.313. View

Burga A, Fadare O, Lininger R, Tavassoli F . Invasive carcinomas of the male breast: a morphologic study of the distribution of histologic subtypes and metastatic patterns in 778 cases. Virchows Arch. 2006; 449(5):507-12. PMC: 1888721. DOI: 10.1007/s00428-006-0305-3. View

Schneider J . Invasive papillary breast carcinoma: mammographic and sonographic appearance. Radiology. 1989; 171(2):377-9. DOI: 10.1148/radiology.171.2.2649917. View

Louwman M, Vriezen M, van Beek M, Tutein Nolthenius-Puylaert M, van der Sangen M, Roumen R . Uncommon breast tumors in perspective: incidence, treatment and survival in the Netherlands. Int J Cancer. 2007; 121(1):127-35. DOI: 10.1002/ijc.22625. View

10.

Ni Y, Tse G . Pathological criteria and practical issues in papillary lesions of the breast - a review. Histopathology. 2016; 68(1):22-32. DOI: 10.1111/his.12866. View

11.

Tay T, Tan P . Papillary neoplasms of the breast-reviewing the spectrum. Mod Pathol. 2021; 34(6):1044-1061. DOI: 10.1038/s41379-020-00732-3. View

12.

Lim G, Chinthala J, Gudi M . Invasive papillary breast cancer with Paget's disease: first reported association and literature review. BMJ Case Rep. 2018; 2018. PMC: 5786974. DOI: 10.1136/bcr-2017-222817. View

13.

Caldarella A, Buzzoni C, Crocetti E, Bianchi S, Vezzosi V, Apicella P . Invasive breast cancer: a significant correlation between histological types and molecular subgroups. J Cancer Res Clin Oncol. 2012; 139(4):617-23. DOI: 10.1007/s00432-012-1365-1. View

14.

Masili-Oku S, Almeida B, Bacchi C, Filassi J, Baracat E, Carvalho F . Lymphocyte-predominant triple-negative breast carcinomas in premenopausal patients: Lower expression of basal immunohistochemical markers. Breast. 2016; 31:34-39. DOI: 10.1016/j.breast.2016.10.012. View

15.

Mitnick J, Vazquez M, Harris M, Schechter S, Roses D . Invasive papillary carcinoma of the breast: mammographic appearance. Radiology. 1990; 177(3):803-6. DOI: 10.1148/radiology.177.3.2243993. View

16.

Liu Z, Liu N, Wang Y, Yang C, Zhang J, Lv S . Clinicopathologic characteristics and molecular subtypes of invasive papillary carcinoma of the breast: a large case study. J Cancer Res Clin Oncol. 2012; 139(1):77-84. DOI: 10.1007/s00432-012-1302-3. View

17.

Alexiev B, Boschnakova Z, Prokopanov C . The apocrine carcinoma of the breast. A cytological, immunohistochemical and ultrastructural study of 6 cases. Zentralbl Pathol. 1994; 140(2):129-34. View

18.

Tan P, Schnitt S, van de Vijver M, Ellis I, Lakhani S . Papillary and neuroendocrine breast lesions: the WHO stance. Histopathology. 2014; 66(6):761-70. DOI: 10.1111/his.12463. View

19.

Zheng Y, Hu X, Shao Z . Clinicopathological Characteristics and Survival Outcomes in Invasive Papillary Carcinoma of the Breast: A SEER Population-Based Study. Sci Rep. 2016; 6:24037. PMC: 4823738. DOI: 10.1038/srep24037. View

20.

Darvishian F, Konno F, Qian M, Cangiarella J . Breast carcinoma with tubulopapillary features: a variant of papillary carcinoma with a stronger correlation with predictors of adverse prognosis. Int J Surg Pathol. 2013; 22(1):47-54. DOI: 10.1177/1066896913501381. View