Macrophage, a Potential Targeted Therapeutic Immune Cell for Cardiomyopathy

Overview

Journal Front Cell Dev Biol

Specialty Cell Biology

Date 2022 Oct 17

PMID 36247005

Authors

Ganyi Chen

Hongwei Jiang

Yiwei Yao

Zhonghao Tao

Wen Chen

Fuhua Huang

Xin Chen

Affiliations

Soon will be listed here.

Abstract

Cardiomyopathy is a major cause of heart failure, leading to systolic and diastolic dysfunction and promoting adverse cardiac remodeling. Macrophages, as key immune cells of the heart, play a crucial role in inflammation and fibrosis. Moreover, exogenous and cardiac resident macrophages are functionally and phenotypically different during cardiac injury. Although experimental evidence has shown that macrophage-targeted therapy is promising in cardiomyopathy, clinical translation remains challenging. In this article, the molecular mechanism of macrophages in cardiomyopathy has been discussed in detail based on existing literature. The issues and considerations of clinical treatment strategies for myocardial fibrosis has also been analyzed.

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