Health-related Quality of Life and Its Predictors Among People Living with Epilepsy at Dessie Referral Hospital, Amhara, Ethiopia: A Cross-sectional Study

Overview

Journal SAGE Open Med

Publisher Sage Publications

Specialty General Medicine

Date 2022 Oct 17

PMID 36246536

Authors

Alebachew Sisay Stotaw

Prem Kumar

Dessale Abate Beyene

Tamrat Assefa Tadesse

Alfoalem Araba Abiye

Affiliations

Soon will be listed here.

Abstract

Objectives: Health-related quality of life of people living with epilepsy is significantly impaired. The disease causes a significant psychological and social impact on daily living conditions and usually has lifelong consequences for the patient and family. Therefore, this study aimed to investigate the health-related quality of life of people living with epilepsy and its predictors in Dessie Referral Hospital, Dessie, Ethiopia.

Methods: A facility-based cross-sectional study was conducted from April to June 2020. Systematic random sampling was used to recruit a total of 385 study participants. Written informed consent was obtained for each participant, and data were collected using World Health Organization Quality of Life Brief Version and Hospital Anxiety and Depression Scale questionnaires. Descriptive statistics were used to summarize the data, while multivariate logistic regression analyses were used to examine factors affecting the quality of life. value ⩽ 0.05 was considered statistically significant.

Results: About 95.80% of the study participants had a generalized seizure, and 64.30% were on two antiepileptic drugs. Of the total, 12.20% and 37.00% suffered from depression and anxiety, respectively, based on the Hospital Anxiety and Depression Scale score. The mean total health-related quality of life score was 51.98 (standard deviation: ± 10.08; 95% confidence interval: 41.90-62.06) out of 100. Age, education level, marital status, occupation, residence, current comorbidity, family support, and recreational activities were associated with good health-related quality of life ( ⩽ 0.05).

Conclusion: The average overall quality of life of people living with epilepsy in the Dessie Referral Hospital was low. Therefore, concerted efforts must be made to improve the quality of life of patients over the healthcare services provided.

Citing Articles

Quality of life and associated factors among people with epilepsy in Ethiopia: a systematic review and meta-analysis.

Andualem F, Melkam M, Tadesse G, Nakie G, Tinsae T, Fentahun S BMC Public Health. 2024; 24(1):1529.

PMID: 38844872 PMC: 11157882. DOI: 10.1186/s12889-024-19018-3.

References

Espinosa-Jovel C, Toledano R, Aledo-Serrano A, Garcia-Morales I, Gil-Nagel A . Epidemiological profile of epilepsy in low income populations. Seizure. 2018; 56:67-72. DOI: 10.1016/j.seizure.2018.02.002. View

Abadiga M, Mosisa G, Amente T, Oluma A . Health-related quality of life and associated factors among epileptic patients on treatment follow up at public hospitals of Wollega zones, Ethiopia, 2018. BMC Res Notes. 2019; 12(1):679. PMC: 6805515. DOI: 10.1186/s13104-019-4720-3. View

Rawlings G, Brown I, Reuber M . Predictors of health-related quality of life in patients with epilepsy and psychogenic nonepileptic seizures. Epilepsy Behav. 2017; 68:153-158. DOI: 10.1016/j.yebeh.2016.10.035. View

Scott R, Lhatoo S, Sander J . The treatment of epilepsy in developing countries: where do we go from here?. Bull World Health Organ. 2001; 79(4):344-51. PMC: 2566404. View

Tefera G, Megersa W, Gadisa D . Health-related quality of life and its determinants among ambulatory patients with epilepsy at Ambo General Hospital, Ethiopia: Using WHOQOL-BREF. PLoS One. 2020; 15(1):e0227858. PMC: 6974038. DOI: 10.1371/journal.pone.0227858. View

Kassahun G, Moges G, Demessie Y . Assessment of Patients' Adherence to Antiepileptic Medications at Dessie Referral Hospital, Chronic Follow-Up, South Wollo, Amhara Region, North East Ethiopia. Neurol Res Int. 2018; 2018:5109615. PMC: 6151205. DOI: 10.1155/2018/5109615. View

Melikyan E, Guekht A, Milchakova L, Lebedeva A, Bondareva I, Gusev E . Health-related quality of life in Russian adults with epilepsy: the effect of socio-demographic and clinical factors. Epilepsy Behav. 2012; 25(4):670-5. DOI: 10.1016/j.yebeh.2012.09.042. View

Siqueira N, Oliveira F, Siqueira J, de Souza E . Quality of life in epilepsy: a study of Brazilian adolescents. PLoS One. 2014; 9(9):e106879. PMC: 4156383. DOI: 10.1371/journal.pone.0106879. View

Kubota H, Awaya Y . Assessment of health-related quality of life and influencing factors using QOLIE-31 in Japanese patients with epilepsy. Epilepsy Behav. 2010; 18(4):381-7. DOI: 10.1016/j.yebeh.2010.04.045. View

10.

Edefonti V, Bravi F, Turner K, Beghi E, Canevini M, Ferraroni M . Health-related quality of life in adults with epilepsy: the effect of age, age at onset and duration of epilepsy in a multicentre Italian study. BMC Neurol. 2011; 11:33. PMC: 3062600. DOI: 10.1186/1471-2377-11-33. View

11.

Kinyanjui D, Kathuku D, Mburu J . Quality of life among patients living with epilepsy attending the neurology clinic at Kenyatta National Hospital, Nairobi, Kenya: a comparative study. Health Qual Life Outcomes. 2013; 11:98. PMC: 3689646. DOI: 10.1186/1477-7525-11-98. View

12.

Pourhoseingholi M, Vahedi M, Rahimzadeh M . Sample size calculation in medical studies. Gastroenterol Hepatol Bed Bench. 2014; 6(1):14-7. PMC: 4017493. View

13.

Gebre A, Haylay A . Sociodemographic, Clinical Variables, and Quality of Life in Patients with Epilepsy in Mekelle City, Northern Ethiopia. Behav Neurol. 2019; 2018:7593573. PMC: 6305035. DOI: 10.1155/2018/7593573. View

14.

Zigmond A, SNAITH R . The hospital anxiety and depression scale. Acta Psychiatr Scand. 1983; 67(6):361-70. DOI: 10.1111/j.1600-0447.1983.tb09716.x. View

15.

Basu S, Sanyal D, Ghosal M, Roy B, Senapati A, Das S . Psychometric properties of Bengali version of QOLIE-10 in epileptic patients. Ann Indian Acad Neurol. 2009; 11(1):28-32. PMC: 2781141. DOI: 10.4103/0972-2327.40222. View

16.

Norsaadah B, Zainab J, Knight A . The quality of life of people with epilepsy at a tertiary referral centre in Malaysia. Health Qual Life Outcomes. 2013; 11:143. PMC: 3765436. DOI: 10.1186/1477-7525-11-143. View

17.

Scheffer I, Berkovic S, Capovilla G, Connolly M, French J, Guilhoto L . ILAE classification of the epilepsies: Position paper of the ILAE Commission for Classification and Terminology. Epilepsia. 2017; 58(4):512-521. PMC: 5386840. DOI: 10.1111/epi.13709. View

18.

Lin C, Pakpour A . Using Hospital Anxiety and Depression Scale (HADS) on patients with epilepsy: Confirmatory factor analysis and Rasch models. Seizure. 2016; 45:42-46. DOI: 10.1016/j.seizure.2016.11.019. View

19.

Raty L, Larsson B . Quality of life in young adults with uncomplicated epilepsy. Epilepsy Behav. 2006; 10(1):142-7. DOI: 10.1016/j.yebeh.2006.09.010. View

20.

Nabukenya A, Matovu J, Wabwire-Mangen F, Wanyenze R, Makumbi F . Health-related quality of life in epilepsy patients receiving anti-epileptic drugs at National Referral Hospitals in Uganda: a cross-sectional study. Health Qual Life Outcomes. 2014; 12:49. PMC: 3999846. DOI: 10.1186/1477-7525-12-49. View