Andrographolide, a Natural Anti-inflammatory Agent: An Update

Overview

Journal Front Pharmacol

Date 2022 Oct 14

PMID 36238575

Authors

Xiaohong Li

Weichen Yuan

Jibiao Wu

Jianhua Zhen

Qihui Sun

Minmin Yu

Affiliations

Soon will be listed here.

Abstract

Botanicals have attracted much attention in the field of anti-inflammatory due to their good pharmacological activity and efficacy. is a natural plant ingredient that is widely used around the world. Andrographolide is the main active ingredient derived from , which has a good effect on the treatment of inflammatory diseases. This article reviews the application, anti-inflammatory mechanism and molecular targets of andrographolide in different inflammatory diseases, including respiratory, digestive, immune, nervous, cardiovascular, skeletal, and tumor system diseases. And describe its toxicity and explain its safety. Studies have shown that andrographolide can be used to treat inflammatory lesions of various systemic diseases. In particular, it acts on many inflammation-related signalling pathways. The future direction of andrographolide research is also introduced, as is the recent research that indicates its potential clinical application as an anti-inflammatory agent.

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