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Positive Effect of a Pea-Clam Two-Peptide Composite on Hypertension and Organ Protection in Spontaneously Hypertensive Rats

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Journal Nutrients
Date 2022 Oct 14
PMID 36235721
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Abstract

In the present study, we prepared pea peptides with high angiotensin-converting enzyme (ACE) inhibitory activity in vitro using an enzymatic hydrolysis of pea protein and compounded them with clam peptides to obtain a pea-clam double peptide. The effects of the two-peptide composite and pea peptides on hypertension and the damage-repair of corresponding organs were studied in spontaneously hypertensive rats (SHRs). We found that both pea peptides and the two-peptide composite significantly reduced the blood pressure upon a single or long-term intragastric administration, with the two-peptide composite being more effective. Mechanistically, we found that the two-peptide composite could regulate the renal renin-angiotensin system (RAS), rebalance gut microbial dysbiosis, decrease renal and myocardial fibrosis, and improve renal and cardiac function and vascular remodeling. Additionally, hippocampal lesions caused by hypertension were also eliminated after two-peptide composite administration. Our research provides a scientific basis for the use of this two-peptide composite as a safe antihypertension ingredient in functional foods.

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References
1.
Verhaar B, Prodan A, Nieuwdorp M, Muller M . Gut Microbiota in Hypertension and Atherosclerosis: A Review. Nutrients. 2020; 12(10). PMC: 7601560. DOI: 10.3390/nu12102982. View

2.
Jia Y, Li T, Han P, Chen Y, Pan L, Jia C . Effects of different courses of moxibustion treatment on intestinal flora and inflammation of a rat model of knee osteoarthritis. J Integr Med. 2022; 20(2):173-181. DOI: 10.1016/j.joim.2022.01.004. View

3.
Nowacki D, Martynowicz H, Skoczynska A, Wojakowska A, Turczyn B, Bobak L . Lecithin derived from ω-3 PUFA fortified eggs decreases blood pressure in spontaneously hypertensive rats. Sci Rep. 2017; 7(1):12373. PMC: 5620069. DOI: 10.1038/s41598-017-12019-w. View

4.
Hamrahian S, Falkner B . Hypertension in Chronic Kidney Disease. Adv Exp Med Biol. 2016; 956:307-325. DOI: 10.1007/5584_2016_84. View

5.
Moon J . ACE2 and Angiotensin-(1-7) in Hypertensive Renal Disease. Electrolyte Blood Press. 2012; 9(2):41-4. PMC: 3302904. DOI: 10.5049/EBP.2011.9.2.41. View