» Articles » PMID: 36235552

Haskap Berry Leaves ( L.)-The Favorable Potential of Medical Use

Overview
Journal Nutrients
Date 2022 Oct 14
PMID 36235552
Authors
Affiliations
Soon will be listed here.
Abstract

The presented research evaluates the medical use potential of leaves, which are waste plants in cultivating berries. The study's screening activity included the leaves of five varieties of : Atut, Duet, Wojtek, Zojka, and Jugana. The microbiological analysis confirmed the safety of using leaves without significant stabilization. leaves standardization was carried out based on the results of the chromatographic analysis, and it showed differences in the contents of active compounds (loganic, chlorogenic and caffeic acids, and rutin), which are attributed to biological activity. For the leaves varieties tested, the differences in the content of total polyphenol content, chlorophylls, and carotenoids were also confirmed. The screening of biological activity of five leaf varieties was carried out concerning the possibility of inhibiting the activity of α-glucosidase, lipase, and hyaluronidase as well, and the antioxidant potential was determined. The defined profile of the biological activity of leaves makes it possible to indicate this raw material as an essential material supporting the prevention and treatment of type II diabetes. However, this research showed that tested enzymes were strongly inhibited by the variety Jugana. The health-promoting potential of leaves was correlated with the highest chlorogenic acid and rutin content in the variety Jugana.

Citing Articles

Effects of Growth Stages on Leaf Nutrients, Metabolites, and Polyphenols of Three Varieties of Haskap.

Emenike C, Azeez S, English M, Udenigwe C, Abbey L Foods. 2024; 13(23).

PMID: 39682834 PMC: 11640610. DOI: 10.3390/foods13233762.


A Systematic Review of Cardio-Metabolic Properties of L.

Bora L, Lombrea A, Batrina S, Buda V, Esanu O, Pasca O Antioxidants (Basel). 2024; 13(6).

PMID: 38929133 PMC: 11201247. DOI: 10.3390/antiox13060694.


Exploring Beneficial Properties of Haskap Berry Leaf Compounds for Gut Health Enhancement.

Sip S, Sip A, Szulc P, Selwet M, Zarowski M, Czerny B Antioxidants (Basel). 2024; 13(3).

PMID: 38539890 PMC: 10968585. DOI: 10.3390/antiox13030357.


Genistein Co-Amorphous Systems with Amino Acids: An Investigation into Enhanced Solubility and Biological Activity.

Garbiec E, Rosiak N, Zalewski P, Tajber L, Cielecka-Piontek J Pharmaceutics. 2023; 15(12).

PMID: 38139995 PMC: 10747361. DOI: 10.3390/pharmaceutics15122653.


The Chemical Profile, Antioxidant, and Anti-Lipid Droplet Activity of Fluid Extracts from Romanian Cultivars of Haskap Berries, Bitter Cherries, and Red Grape Pomace for the Management of Liver Steatosis.

Craciunescu O, Seciu-Grama A, Mihai E, Utoiu E, Negreanu-Pirjol T, Lupu C Int J Mol Sci. 2023; 24(23).

PMID: 38069172 PMC: 10706173. DOI: 10.3390/ijms242316849.


References
1.
Lewis D, Liu D . Direct Measurement of Lipase Inhibition by Orlistat Using a Dissolution Linked Assay. Clin Pharmacol Biopharm. 2014; 1. PMC: 4238884. DOI: 10.4172/2167-065X.1000103. View

2.
Enogieru A, Haylett W, Hiss D, Bardien S, Ekpo O . Rutin as a Potent Antioxidant: Implications for Neurodegenerative Disorders. Oxid Med Cell Longev. 2018; 2018:6241017. PMC: 6040293. DOI: 10.1155/2018/6241017. View

3.
Han M, Lee W, Nagappan A, Hong S, Jung J, Park C . Flavonoids Isolated from Flowers of Lonicera japonica Thunb. Inhibit Inflammatory Responses in BV2 Microglial Cells by Suppressing TNF-α and IL-β Through PI3K/Akt/NF-kb Signaling Pathways. Phytother Res. 2016; 30(11):1824-1832. DOI: 10.1002/ptr.5688. View

4.
Blainski A, Lopes G, de Mello J . Application and analysis of the folin ciocalteu method for the determination of the total phenolic content from Limonium brasiliense L. Molecules. 2013; 18(6):6852-65. PMC: 6270247. DOI: 10.3390/molecules18066852. View

5.
Lee Y, Cho I, Kim J, Lee M, Ku S, Choi J . Hepatoprotective effects of blue honeysuckle on CCl-induced acute liver damaged mice. Food Sci Nutr. 2019; 7(1):322-338. PMC: 6341158. DOI: 10.1002/fsn3.893. View