Chemical Constituents of and Their Anti-Pancreatic Cancer Activity Against Human PANC-1 Cell Line

Overview

Journal Plants (Basel)

Date 2022 Oct 14

PMID 36235333

Authors

Juthamart Maneenet

Ahmed M Tawila

Ashraf M Omar

Nguyen Duy Phan

Chiharu Ojima

Masahiro Kuroda

Mao Sato

Mio Mizoguchi

Ikue Takahashi

Suresh Awale

Affiliations

Soon will be listed here.

Abstract

An n-hexane extract of was found to exhibit potent cytotoxicity against PANC-1 human pancreatic cancer cells, preferentially under nutrition starvation conditions, with a PC value of 6.2 µg/mL. Phytochemical investigation of this bioactive extract resulted in the isolation of fifteen compounds (-), including a new compound, subulatone A (-). The structure of compound was elucidated using HRFABMS and NMR spectroscopic analyses. The isolated compounds were tested for their preferential cytotoxicity against the PANC-1 human pancreatic cancer cell line, using an anti-austerity strategy. Among these, myrtucommulone A () showed highly potent preferential cytotoxicity, with a PC value of 0.28 µM. Myrtucommulone A () was found to alter PANC-1 cell morphology, inhibit cell migration, and downregulate the PI3K/Akt/mTOR and autophagy signaling pathways in nutrient-deprived media, leading to cancer cell death. Therefore, myrtucommulone A () is a lead compound for anticancer drug development based on an anti-austerity strategy.

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