Frequency, Characteristics, and Predictive Factors of Adverse Drug Events in an Adult Emergency Department According to Age: A Cross-Sectional Study

Overview

Journal J Clin Med

Specialty General Medicine

Date 2022 Oct 14

PMID 36233599

Authors

Laura Lohan

Gregory Marin

Marie Faucanie

Marion Laureau

Damien Perier

Veronique Pinzani

Isabelle Giraud

Maxime Villiet

Mustapha Sebbane

Ariane Sultan

Cyril Breuker

Affiliations

Soon will be listed here.

Abstract

Adverse drug events (ADEs) are a major public health concern, given their consequences in terms of morbi-mortality and associated healthcare costs. Many studies have focused on the elderly, who are considered particularly vulnerable in this respect. We aimed to determine and compare the frequency, characteristics, and predictive factors of ADEs according to age in an adult population. A prospective seven-year cross-sectional study was conducted in a university hospital emergency department. Structured medication reviews and ADE detection were performed. Patient data and ADE characteristics were collected. Descriptive statistics and logistic regression were performed in two age groups: Group 1 (age < 65 years) and 2 (age ≥ 65 years). Among the 13,653 patients included, 18.4% in Group 1 and 22.6% in Group 2 experienced an ADE. Differences were identified in terms of the ADE type (more ADEs due to noncompliance in Group 1) and ADE symptoms (greater bleeding in Group 2). In the multivariable analysis, several specific predictive factors were identified, including kidney failure and antidiabetic drug use in Group 1 and inappropriate prescription and antithrombotic treatment in Group 2. Analysis by age provided a more refined vision of ADEs as we identified distinct profiles of iatrogenesis. These results will lead to a better detection of ADEs.

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