Opportunities and Limits of Conventional IVF Versus ICSI: It Is Time to Come off the Fence

Overview

Journal J Clin Med

Specialty General Medicine

Date 2022 Oct 14

PMID 36233589

Authors

Martina Balli

Anna Cecchele

Valerio Pisaturo

Sofia Makieva

Giorgia Carullo

Edgardo Somigliana

Alessio Paffoni

Paola Vigano

Affiliations

Soon will be listed here.

Abstract

Conventional IVF (c-IVF) is one of the most practiced assisted reproductive technology (ART) approaches used worldwide. However, in the last years, the number of c-IVF procedures has dropped dramatically in favor of intracytoplasmic sperm injection (ICSI) in cases of non-male-related infertility. In this review, we have outlined advantages and disadvantages associated with c-IVF, highlighting the essential steps governing its success, its limitations, the methodology differences among laboratories and the technical progress. In addition, we have debated recent insights into fundamental questions, including indications regarding maternal age, decreased ovarian reserve, endometriosis, autoimmunity, single oocyte retrieval-cases as well as preimplantation genetic testing cycles. The "overuse" of ICSI procedures in several clinical situations of ART has been critically discussed. These insights will provide a framework for a better understanding of opportunities associated with human c-IVF and for best practice guidelines applicability in the reproductive medicine field.

Citing Articles

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Intracytoplasmic sperm injection compared with in vitro fertilisation in patients with non-male factor infertility with low oocyte retrieval: a single-centre, retrospective cohort study.

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Risk Factors for Prematurity and Congenital Malformations in Assisted Reproductive Technology Pregnancies-A Retrospective Study.

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Racial/ethnic disparity in severe maternal morbidity among women who conceived by in vitro fertilization.

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Conventional IVF performs similarly in women with and without endometriosis.

Vigano P, Reschini M, Ciaffaglione M, Cuce V, Casalechi M, Benaglia L J Assist Reprod Genet. 2023; 40(3):599-607.

PMID: 36637584 PMC: 10033814. DOI: 10.1007/s10815-022-02700-z.

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