and Its Culture Supernatant Alleviate the -Induced Endometritis in Mice

Overview

Journal Animals (Basel)

Date 2022 Oct 14

PMID 36230459

Authors

Cholryong Mun

Jiapei Cai

Xiaoyu Hu

Wenlong Zhang

Naisheng Zhang

Yongguo Cao

Affiliations

Soon will be listed here.

Abstract

Endometritis is a disease with a high incidence in dairy cows and causes great economic loss to milk production. This study examined the therapeutic effects of and its culture supernatant on -induced endometritis in mice. The results showed that and its culture supernatant effectively suppressed inflammatory responses of uterine tissues, such as uterine morphological changes, pathological damage, and the production of inflammatory cytokines. and its culture supernatant significantly decreased uterine microbial loads. In addition, and its culture supernatant restored reproduction outcomes in -induced endometritis mice. Western blot analysis showed that and its culture supernatant suppressed the NF-κB signaling pathway. Therefore, the anti-inflammatory mechanism of and its culture supernatant may occur through the anti-bacterial activity and regulation of the expression of NF-κB in the uterus. The anti-inflammatory effect of the culture supernatant of was slightly better than that of viable . Therefore, our experimental results showed that culture supernatant may be an effective drug for treating endometritis.

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