Development of a Novel Small-animal Myocardial Phantom Can Evaluate the Image Quality of Dual-isotope Simultaneous Acquisition (DISA)

Overview

Journal Ann Nucl Med

Date 2022 Oct 13

PMID 36227465

Authors

Takayuki Shibutani

Masahisa Onoguchi

Takayuki Kanno

Hiroshi Wakabayashi

Tomo Hiromasa

Seigo Kinuya

Affiliations

Soon will be listed here.

Abstract

Background: Myocardial phantom studies are widely used as a tool to accurately assess the physical phenomenon of dual-isotope simultaneous acquisition (DISA) in the small-animal fields. However, the previous phantom did not reproduce the structures of rats or mice. The aim of this study was to develop a novel myocardial phantom simulating the structure of a small animal that can be evaluated using the image quality of DISA.

Methods: A novel small-animal myocardial phantom that simulated a rat was constructed by the myocardium, liver, lung, spine, and torso. Normal and inferior wall defect myocardial phantoms were filled with Tc or F solution to simulate single-isotope acquisition (SIA) and DISA. Phantom and small-animal images with no scatter correction (nonSC) and scatter correction (SC) were created.

Results: The Tc DISA with SC showed a low %CV compared to that with nonSC. Although the Tc DISA with nonSC had lower cavity contrast than that of Tc SIA with nonSC, the cavity contrast of SC had similar values between SIA and DISA. The minimum %uptake of Tc SIA with nonSC was a lower value compared to that of Tc DISA with nonSC. The Tc DISA was equivalent to the minimum %uptake of Tc SIA by SC.

Conclusion: We have developed a novel myocardial phantom for the rat model to evaluate the image quality for reproducing the physical phenomenon associated with radiation attenuation and scattering. Furthermore, we could demonstrate the usefulness of the novel small-animal myocardial phantom by image quality evaluation of DISA with Tc and F compared to SIA.

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