Nicotinamide Mononucleotide Is Safely Metabolized and Significantly Reduces Blood Triglyceride Levels in Healthy Individuals

Overview

Journal Cureus

Specialty Biomedical Engineering

Date 2022 Oct 13

PMID 36225528

Authors

Shintarou Kimura

Misa Ichikawa

Suzuka Sugawara

Tomoko Katagiri

Yuumi Hirasawa

Takahiro Ishikawa

Wataru Matsunaga

Akinobu Gotoh

Affiliations

Soon will be listed here.

Abstract

An increase in nicotinamide adenine dinucleotide (NAD) levels alleviates age-related disease progression and promotes healthy life expectancy. Several studies have demonstrated that NAD levels can be efficiently replenished via nicotinamide mononucleotide (NMN) intake; additionally, the safety of its oral ingestion has been confirmed in recent clinical trials. However, the efficacy and safety of intravenous NMN administration in humans remain unclear. Therefore, we verified its safety in 10 healthy volunteers. Intravenous administration of NMN did not affect electrocardiograms, pulse, and blood pressure, nor did it affect metabolic markers in the liver, heart, pancreas, and kidneys. These results indicate that intravenous NMN administration is safe and beneficial in humans. Furthermore, NMN administration significantly increased blood NAD levels without damaging blood cells and significantly reduced blood triglyceride (TG) levels. These findings imply that intravenous administration of NMN may lead to the prevention and treatment of diseases associated with increased TG levels, such as fatty liver and diabetes.

Citing Articles

Nicotinamide Mononucleotide Supplementation: Understanding Metabolic Variability and Clinical Implications.

Benjamin C, Crews R Metabolites. 2024; 14(6).

PMID: 38921475 PMC: 11205942. DOI: 10.3390/metabo14060341.

Interactions between Intestinal Homeostasis and NAD Biology in Regulating Incretin Production and Postprandial Glucose Metabolism.

Nagahisa T, Kosugi S, Yamaguchi S Nutrients. 2023; 15(6).

PMID: 36986224 PMC: 10052115. DOI: 10.3390/nu15061494.

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