Defibrinogenation Ameliorates Retinal Microgliosis and Inflammation in A CX3CR1-Independent Manner

Overview

Journal ASN Neuro

Specialties Chemistry
Neurology

Date 2022 Oct 12

PMID 36221892

Authors

Borna Sarker

Sandra M Cardona

Kaira A Church

Difernando Vanegas

Priscila Velazquez

Colin Rorex

Derek Rodriguez

Andrew S Mendiola

Timothy S Kern

Nadia D Domingo

Robin Stephens

Isabel A Muzzio

Astrid E Cardona

Affiliations

Soon will be listed here.

Abstract

Diabetic human and murine retinas revealed pronounced microglial morphological activation and vascular abnormalities associated with inflammation. Pharmacological fibrinogen depletion using ancrod dampened microglial morphology alterations, resolved fibrinogen accumulation, rescued axonal integrity, and reduced inflammation in the diabetic murine retina.

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