» Articles » PMID: 36216859

Impact of Government Policies on the COVID-19 Pandemic Unraveled by Mathematical Modelling

Overview
Journal Sci Rep
Specialty Science
Date 2022 Oct 10
PMID 36216859
Authors
Affiliations
Soon will be listed here.
Abstract

Since the very beginning of the COVID-19 pandemic, control policies and restrictions have been the hope for containing the rapid spread of the virus. However, the psychological and economic toll they take on society entails the necessity to develop an optimal control strategy. Assessment of the effectiveness of these interventions aided with mathematical modelling remains a non-trivial issue in terms of numerical conditioning due to the high number of parameters to estimate from a highly noisy dataset and significant correlations between policy timings. We propose a solution to the problem of parameter non-estimability utilizing data from a set of European countries. Treating a subset of parameters as common for all countries and the rest as country-specific, we construct a set of individualized models incorporating 13 different pandemic control measures, and estimate their parameters without prior assumptions. We demonstrate high predictive abilities of these models on an independent validation set and rank the policies by their effectiveness in reducing transmission rates. We show that raising awareness through information campaigns, providing income support, closing schools and workplaces, cancelling public events, and maintaining an open testing policy have the highest potential to mitigate the pandemic.

References
1.
Kohler J, Schwenkel L, Koch A, Berberich J, Pauli P, Allgower F . Robust and optimal predictive control of the COVID-19 outbreak. Annu Rev Control. 2020; 51:525-539. PMC: 7757387. DOI: 10.1016/j.arcontrol.2020.11.002. View

2.
Quesada J, Lopez-Pineda A, Gil-Guillen V, Arriero-Marin J, Gutierrez F, Carratala-Munuera C . Incubation period of COVID-19: A systematic review and meta-analysis. Rev Clin Esp (Barc). 2021; 221(2):109-117. PMC: 7698828. DOI: 10.1016/j.rceng.2020.08.002. View

3.
Auger K, Shah S, Richardson T, Hartley D, Hall M, Warniment A . Association Between Statewide School Closure and COVID-19 Incidence and Mortality in the US. JAMA. 2020; 324(9):859-870. PMC: 7391181. DOI: 10.1001/jama.2020.14348. View

4.
Viner R, Russell S, Croker H, Packer J, Ward J, Stansfield C . School closure and management practices during coronavirus outbreaks including COVID-19: a rapid systematic review. Lancet Child Adolesc Health. 2020; 4(5):397-404. PMC: 7270629. DOI: 10.1016/S2352-4642(20)30095-X. View

5.
Silva C, Cruz C, Torres D, Munuzuri A, Carballosa A, Area I . Optimal control of the COVID-19 pandemic: controlled sanitary deconfinement in Portugal. Sci Rep. 2021; 11(1):3451. PMC: 7876047. DOI: 10.1038/s41598-021-83075-6. View