Gluing Blood into Gel by Electrostatic Interaction Using a Water-soluble Polymer As an Embolic Agent

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2022 Oct 10

PMID 36215508

Authors

Zhiping Jin

Hailong Fan

Toshiya Osanai

Takayuki Nonoyama

Takayuki Kurokawa

Hideki Hyodoh

Kotaro Matoba

Akiko Takeuchi

Jian Ping Gong

Miki Fujimura

Affiliations

Soon will be listed here.

Abstract

Liquid embolic agents are widely used for the endovascular embolization of vascular conditions. However, embolization based on phase transition is limited by the adhesion of the microcatheter to the embolic agent, use of an organic solvent, unintentional catheter retention, and other complications. By mimicking thrombus formation, a water-soluble polymer that rapidly glues blood into a gel without triggering coagulation was developed. The polymer, which consists of cationic and aromatic residues with adjacent sequences, shows electrostatic adhesion with negatively charged blood substances in a physiological environment, while common polycations cannot. Aqueous polymer solutions are injectable through clinical microcatheters and needles. The formed blood gel neither adhered to the catheter nor blocked the port. Postoperative computed tomography imaging showed that the polymer can block the rat femoral artery in vivo and remain at the injection site without nontarget embolization. This study provides an alternative for the development of waterborne embolic agents.

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References

Jones J, Sima M, OHara R, Stewart R . Water-Borne Endovascular Embolics Inspired by the Undersea Adhesive of Marine Sandcastle Worms. Adv Healthc Mater. 2016; 5(7):795-801. PMC: 5703062. DOI: 10.1002/adhm.201500825. View

Schmitt N, Floca R, Paech D, El Shafie R, Seker F, Bendszus M . Imaging Artifacts of Liquid Embolic Agents on Conventional CT in an Experimental in Vitro Model. AJNR Am J Neuroradiol. 2020; 42(1):126-131. PMC: 7814783. DOI: 10.3174/ajnr.A6867. View

Shahidi M, Vatanmakanian M, Kourosh Arami M, Shirazi F, Esmaeili N, Hydarporian S . A comparative study between platelet-rich plasma and platelet-poor plasma effects on angiogenesis. Med Mol Morphol. 2017; 51(1):21-31. DOI: 10.1007/s00795-017-0168-5. View

Fan L, Duan M, Xie Z, Pan K, Wang X, Sun X . Injectable and Radiopaque Liquid Metal/Calcium Alginate Hydrogels for Endovascular Embolization and Tumor Embolotherapy. Small. 2019; 16(2):e1903421. DOI: 10.1002/smll.201903421. View

Poursaid A, Jensen M, Huo E, Ghandehari H . Polymeric materials for embolic and chemoembolic applications. J Control Release. 2016; 240:414-433. PMC: 5001944. DOI: 10.1016/j.jconrel.2016.02.033. View

Yang H, Lei K, Zhou F, Yang X, An Q, Zhu W . Injectable PEG/polyester thermogel: A new liquid embolization agent for temporary vascular interventional therapy. Mater Sci Eng C Mater Biol Appl. 2019; 102:606-615. DOI: 10.1016/j.msec.2019.04.075. View

Mueller L, Theurich S, Christopeit M, Grothe W, Muetherig A, Weber T . Neurotoxicity upon infusion of dimethylsulfoxide-cryopreserved peripheral blood stem cells in patients with and without pre-existing cerebral disease. Eur J Haematol. 2007; 78(6):527-31. DOI: 10.1111/j.1600-0609.2007.00851.x. View

Cilurzo F, Selmin F, Minghetti P, Adami M, Bertoni E, Lauria S . Injectability evaluation: an open issue. AAPS PharmSciTech. 2011; 12(2):604-9. PMC: 3134656. DOI: 10.1208/s12249-011-9625-y. View

Soulez G, Gilbert Md Frcpc P, Giroux Md Frcpc M, Racicot Md Frcpc J, Dubois J . Interventional Management of Arteriovenous Malformations. Tech Vasc Interv Radiol. 2019; 22(4):100633. DOI: 10.1016/j.tvir.2019.100633. View

10.

Ko G, Choi J, Shin K, Kim Y, Kang T, Kim D . In Vivo Sol-Gel Reaction of Tantalum Alkoxide for Endovascular Embolization. Adv Healthc Mater. 2021; 11(4):e2101908. DOI: 10.1002/adhm.202101908. View

11.

Hu J, Albadawi H, Chong B, Deipolyi A, Sheth R, Khademhosseini A . Advances in Biomaterials and Technologies for Vascular Embolization. Adv Mater. 2019; 31(33):e1901071. PMC: 7014563. DOI: 10.1002/adma.201901071. View

12.

Pan P, Weinsheimer S, Cooke D, Winkler E, Abla A, Kim H . Review of treatment and therapeutic targets in brain arteriovenous malformation. J Cereb Blood Flow Metab. 2021; 41(12):3141-3156. PMC: 8669284. DOI: 10.1177/0271678X211026771. View

13.

Walayat S, Martin D, Patel J, Ahmed U, Asghar M, Pai A . Role of albumin in cirrhosis: from a hospitalist's perspective. J Community Hosp Intern Med Perspect. 2017; 7(1):8-14. PMC: 5463675. DOI: 10.1080/20009666.2017.1302704. View

14.

Schimmel K, Ali M, Tan S, Teng J, Do H, Steinberg G . Arteriovenous Malformations-Current Understanding of the Pathogenesis with Implications for Treatment. Int J Mol Sci. 2021; 22(16). PMC: 8396465. DOI: 10.3390/ijms22169037. View

15.

Lord J, Britton H, Spain S, Lewis A . Advancements in the development on new liquid embolic agents for use in therapeutic embolisation. J Mater Chem B. 2020; 8(36):8207-8218. DOI: 10.1039/d0tb01576h. View

16.

Smith S, Travers R, Morrissey J . How it all starts: Initiation of the clotting cascade. Crit Rev Biochem Mol Biol. 2015; 50(4):326-36. PMC: 4826570. DOI: 10.3109/10409238.2015.1050550. View

17.

Oopik V, Saaremets I, Medijainen L, Karelson K, Janson T, Timpmann S . Effects of sodium citrate ingestion before exercise on endurance performance in well trained college runners. Br J Sports Med. 2003; 37(6):485-9. PMC: 1724692. DOI: 10.1136/bjsm.37.6.485. View

18.

Vollherbst D, Chapot R, Bendszus M, Mohlenbruch M . Glue, Onyx, Squid or PHIL? Liquid Embolic Agents for the Embolization of Cerebral Arteriovenous Malformations and Dural Arteriovenous Fistulas. Clin Neuroradiol. 2021; 32(1):25-38. PMC: 8894162. DOI: 10.1007/s00062-021-01066-6. View

19.

Kaibara M . Rheology of blood coagulation. Biorheology. 1996; 33(2):101-17. DOI: 10.1016/0006-355X(96)00010-8. View

20.

Vo A, Doumit M, Rockwell G . The Biomechanics and Optimization of the Needle-Syringe System for Injecting Triamcinolone Acetonide into Keloids. J Med Eng. 2016; 2016:5162394. PMC: 5098087. DOI: 10.1155/2016/5162394. View