Anticancer Potential of Oroxylin A: from Mechanistic Insight to Synergistic Perspectives

Overview

Journal Naunyn Schmiedebergs Arch Pharmacol

Specialty Pharmacology

Date 2022 Oct 10

PMID 36214865

Authors

Hardeep Singh Tuli

Vivek Kumar Garg

Ajay Kumar

Diwakar Aggarwal

Uttpal Anand

Nidarshana Chaturvedi Parashar

Adesh K Saini

Ranjan K Mohapatra

Kuldeep Dhama

Manoj Kumar

Tejveer Singh

Jagjit Kaur

Katrin Sak

Affiliations

Soon will be listed here.

Abstract

Oroxylin A (OA), a well-known constituent of the root of Scutellariae plants, has been used in ethnomedicine already for centuries in treating various neoplastic disorders. However, only recent molecular studies have revealed the different mechanisms behind its action, demonstrating antiproliferative, anti-inflammatory, and proapoptotic effects, restricting also the spread of cancer cells to distant organs. A variety of cellular targets and modulated signal transduction pathways regulated by OA have been determined in diverse cells derived from different malignant tissues. In this review article, these anticancer activities are thoroughly described, representing OA as a potential lead structure for the design of novel more potent anticancer medicines. In addition, co-effects of this natural compound with conventional anticancer agents are analyzed and the advantages provided by nanotechnological methods for more efficient application of OA are discussed. In this way, OA might represent an excellent example of using ethnopharmacological knowledge for designing modern medicines.

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