» Articles » PMID: 36212639

Recurrence of Chronic Subdural Hematoma Due to Low-grade Infection

Overview
Journal Front Neurol
Specialty Neurology
Date 2022 Oct 10
PMID 36212639
Authors
Affiliations
Soon will be listed here.
Abstract

Despite the high incidence and multitudes of operative techniques, the risk factors for chronic subdural hematoma (CSDH) recurrence are still under debate and a universal consensus on the pathophysiology is lacking. We hypothesized that clinically inapparent, a low-grade infection could be responsible for CSDH recurrence. This investigation is a single-center prospective observational study including patients with recurrent CSDH. In total, 44 patients with CSDH recurrence received an intraoperative swab-based microbiological test. The intraoperative swab revealed an inapparent low-grade hematoma infection in 29% of the recurrent CSDH cases. The majority (69%) of the identified germs belonged to the genus. We therefore, propose a novel potential pathophysiology for CSDH recurrence.

Citing Articles

The Use of Adjuvant Dexamethasone in Chronic Subdural Hematoma After Surgery.

Cine H Cureus. 2023; 15(8):e44086.

PMID: 37638268 PMC: 10450569. DOI: 10.7759/cureus.44086.

References
1.
Shrestha D, Budhathoki P, Sedhai Y, Jain S, Karki P, Jha P . Steroid in Chronic Subdural Hematoma: An Updated Systematic Review and Meta-Analysis Post DEX-CSDH Trial. World Neurosurg. 2021; 158:84-99. DOI: 10.1016/j.wneu.2021.10.167. View

2.
Isaji T, Osuka K, Ohmichi Y, Ohmichi M, Naito M, Nakano T . Expression of Angiopoietins and Angiogenic Signaling Pathway Molecules in Chronic Subdural Hematomas. J Neurotrauma. 2020; 37(23):2493-2498. DOI: 10.1089/neu.2020.7042. View

3.
Hutchinson P, Edlmann E, Bulters D, Zolnourian A, Holton P, Suttner N . Trial of Dexamethasone for Chronic Subdural Hematoma. N Engl J Med. 2020; 383(27):2616-2627. DOI: 10.1056/NEJMoa2020473. View

4.
Kan P, Maragkos G, Srivatsan A, Srinivasan V, Johnson J, Burkhardt J . Middle Meningeal Artery Embolization for Chronic Subdural Hematoma: A Multi-Center Experience of 154 Consecutive Embolizations. Neurosurgery. 2020; 88(2):268-277. DOI: 10.1093/neuros/nyaa379. View

5.
Weigel R, Hohenstein A, Schilling L . Vascular endothelial growth factor concentration in chronic subdural hematoma fluid is related to computed tomography appearance and exudation rate. J Neurotrauma. 2013; 31(7):670-3. PMC: 3961767. DOI: 10.1089/neu.2013.2884. View