Immune Function of Patients with Gastrointestinal Carcinoma After Treatment with Multiple Infusions of Monoclonal Antibody 17.1A

Overview

Journal Cancer Res

Specialty Oncology

Date 1987 Oct 1

PMID 3621210

Citations 7

Authors

H M Blottiere

C Maurel

J Y Douillard

Affiliations

Soon will be listed here.

Abstract

Ten patients with metastatic adenocarcinomas of the colon or pancreas were treated with multiple injections of monoclonal antibody 17.1A. For each injection, antibody concentration in the patients' sera plateaued during the entire treatment course, and then decreased, with faster antibody clearance in patients given previous injections of mouse monoclonal antibodies for immunoscintigraphy. Six of the ten patients were able to generate anti-mouse antibodies, detectable 7 days after the initial infusion. Peripheral blood mononuclear cells from patients showed only low level ability to mediate spontaneous and antibody-dependent cytotoxicity in vitro, both before monoclonal antibody treatment and during the entire treatment period. Undiluted sera from these patients were unable to generate antibody-dependent cytotoxicity activity in vitro at any time during the observation period.

Citing Articles

Decreased renal accumulation of biotinylated chimeric monoclonal antibody-neocarzinostatin conjugate after administration of avidin.

Otsuji E, Yamaguchi T, Yamamoto K, Matsumura H, Tsuruta H, YATA Y Jpn J Cancer Res. 1997; 88(2):205-12.

PMID: 9119750 PMC: 5921355. DOI: 10.1111/j.1349-7006.1997.tb00367.x.

Effects of neocarzinostatin-chimeric Fab conjugates on the growth of human pancreatic carcinoma xenografts.

Otsuji E, Yamaguchi T, Tsuruta H, YATA Y, Nishi H, Okamoto K Br J Cancer. 1996; 73(10):1178-82.

PMID: 8630275 PMC: 2074529. DOI: 10.1038/bjc.1996.227.

Haga Y, Sivinski C, Woo D, Tempero M Int J Pancreatol. 1994; 15(1):43-50.

PMID: 8195641 DOI: 10.1007/BF02924387.

Biodistribution of neocarzinostatin conjugated to chimeric Fab fragments of the monoclonal antibody A7 in nude mice bearing human pancreatic cancer xenografts.

Otsuji E, Yamaguchi T, Yamaoka N, Taniguchi K, Kato M, Kotani T Jpn J Cancer Res. 1994; 85(5):530-5.

PMID: 8014111 PMC: 5919492. DOI: 10.1111/j.1349-7006.1994.tb02391.x.

Experience with the iodine-123 and technetium-99m labelled anti-granulocyte antibody MAb47: a comparison of labelling methods.

Blauenstein P, Locher J, Seybold K, Koprivova H, Janoki G, Macke H Eur J Nucl Med. 1995; 22(7):690-8.

PMID: 7498233 DOI: 10.1007/BF01254573.