Global Burden of Cardiomyopathy and Myocarditis in the Older Adults from 1990 to 2019

Overview

Journal Front Public Health

Specialty Public Health

Date 2022 Oct 10

PMID 36211688

Authors

Kexin Zhang

Xuebing Cheng

Na Qu

Hongwei Song

Youhong Luo

Tongtong Ye

Qian Xu

Hongzhan Tian

Chengxia Kan

Ningning Hou

Affiliations

Soon will be listed here.

Abstract

Background: Cardiomyopathy and myocarditis (CM-MC) are common chronic diseases causing heart failure in older adults. We aimed to analyze the burden of CM-MC in older adults aged 60-89 years at the global, regional, and national levels in 204 countries from 1990 to 2019.

Methods: Detailed data on CM-MC from 1990 to 2019 were analyzed from the Global Burden of Diseases Study 2019, including incidence, mortality, disability-adjusted life years (DALYs) and the proportion of deaths caused by different risks factors. All results are presented as numbers, age-standardized rates per 100,000 person-years and estimated annual percentage change (EAPC) with an uncertainty interval of 95%.

Results: Globally, there were 475,458 (339,942-638,363) incidence cases from CM-MC in 2019; with an age-standardized incidence rate (ASIR) of 16 (13-19.3) per 100,000 person-years. And there were 185,308 (154,610-200,448) deaths, with the age-standardized mortality rate (ASMR) being 4.4 (3.7-4.8). CM-MC resulted in 3,372,716 (2,931,247-3,693,622) DALYs, with an age-standardized DALYs rate (ASDR) of 114.8 (98.7-126.1). Estimated annual percentage change (EAPCs) for ARIS, ARMS, and ARDS has decreased. At the national level, the United States of America had the highest mortality [21,372 (18,924-24,241)] and disability-adjusted life years [407,712 (370,234-470,165)]. And China had the highest number of incident cases [122, 266 (85,925-166,095)]. Globally, high systolic blood pressure and alcohol consumption were the top two risk factors for the proportion of CM-MC deaths.

Conclusion: CM-MC is still an important cause of early death and chronic disability in older adults. Based on this study, public health agencies should seek more effective methods to prevent and treat CM-MC.

Citing Articles

Association between sanitary toilets and health poverty vulnerability among rural western Chinese adults aged 45 years and older: A cross-sectional study.

Ma X, Hu Q, He J, Li C, Chen K, Wang W PLoS One. 2024; 19(9):e0308688.

PMID: 39302976 PMC: 11414992. DOI: 10.1371/journal.pone.0308688.

A study on the factors influencing the vulnerability of women of childbearing age to health poverty in rural western China.

Ma X, Hu Q, He J, Li C, Song M, Wang Y Sci Rep. 2024; 14(1):13219.

PMID: 38851773 PMC: 11162415. DOI: 10.1038/s41598-024-64070-z.

COVID-19, Myocarditis and Pericarditis.

Fairweather D, Beetler D, Di Florio D, Musigk N, Heidecker B, Cooper Jr L Circ Res. 2023; 132(10):1302-1319.

PMID: 37167363 PMC: 10171304. DOI: 10.1161/CIRCRESAHA.123.321878.

Sex and gender differences in myocarditis and dilated cardiomyopathy: An update.

Fairweather D, Beetler D, Musigk N, Heidecker B, Lyle M, Cooper Jr L Front Cardiovasc Med. 2023; 10:1129348.

PMID: 36937911 PMC: 10017519. DOI: 10.3389/fcvm.2023.1129348.

References

. Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 2018; 392(10159):1736-1788. PMC: 6227606. DOI: 10.1016/S0140-6736(18)32203-7. View

Roth G, Johnson C, Abajobir A, Abd-Allah F, Abera S, Abyu G . Global, Regional, and National Burden of Cardiovascular Diseases for 10 Causes, 1990 to 2015. J Am Coll Cardiol. 2017; 70(1):1-25. PMC: 5491406. DOI: 10.1016/j.jacc.2017.04.052. View

Ding D, Zhao Q, Wu W, Xiao Z, Liang X, Luo J . Prevalence and incidence of dementia in an older Chinese population over two decades: The role of education. Alzheimers Dement. 2020; 16(12):1650-1662. DOI: 10.1002/alz.12159. View

Maron B, Towbin J, Thiene G, Antzelevitch C, Corrado D, Arnett D . Contemporary definitions and classification of the cardiomyopathies: an American Heart Association Scientific Statement from the Council on Clinical Cardiology, Heart Failure and Transplantation Committee; Quality of Care and Outcomes Research and.... Circulation. 2006; 113(14):1807-16. DOI: 10.1161/CIRCULATIONAHA.106.174287. View

Cannata A, Merlo M, Artico J, Gentile P, Camparini L, Cristallini J . Cardiovascular aging: the unveiled enigma from bench to bedside. J Cardiovasc Med (Hagerstown). 2018; 19(10):517-526. DOI: 10.2459/JCM.0000000000000694. View

Clark H . NCDs: a challenge to sustainable human development. Lancet. 2013; 381(9866):510-1. DOI: 10.1016/S0140-6736(13)60058-6. View

Lovden M, Fratiglioni L, Glymour M, Lindenberger U, Tucker-Drob E . Education and Cognitive Functioning Across the Life Span. Psychol Sci Public Interest. 2020; 21(1):6-41. PMC: 7425377. DOI: 10.1177/1529100620920576. View

Benetos A, Petrovic M, Strandberg T . Hypertension Management in Older and Frail Older Patients. Circ Res. 2019; 124(7):1045-1060. DOI: 10.1161/CIRCRESAHA.118.313236. View

Dai H, Lotan D, Much A, Younis A, Lu Y, Bragazzi N . Global, Regional, and National Burden of Myocarditis and Cardiomyopathy, 1990-2017. Front Cardiovasc Med. 2021; 8:610989. PMC: 7904878. DOI: 10.3389/fcvm.2021.610989. View

10.

Buggey J, Elamm C . Myocarditis and cardiomyopathy. Curr Opin Cardiol. 2018; 33(3):341-346. DOI: 10.1097/HCO.0000000000000514. View

11.

Dennert R, Crijns H, Heymans S . Acute viral myocarditis. Eur Heart J. 2008; 29(17):2073-82. PMC: 2519249. DOI: 10.1093/eurheartj/ehn296. View

12.

Xie H, Zhang C, Wang Y, Huang S, Cui W, Yang W . Distinct Patterns of Cognitive Aging Modified by Education Level and Gender among Adults with Limited or No Formal Education: A Normative Study of the Mini-Mental State Examination. J Alzheimers Dis. 2016; 49(4):961-9. DOI: 10.3233/JAD-143066. View

13.

Khazaei S, Rezaeian S, Khazaei S, Mansori K, Moghaddam A, Ayubi E . Effects of Human Development Index and Its Components on Colorectal Cancer Incidence and Mortality: a Global Ecological Study. Asian Pac J Cancer Prev. 2016; 17(S3):253-6. DOI: 10.7314/apjcp.2016.17.s3.253. View

14.

Dominguez F, Kuhl U, Pieske B, Garcia-Pavia P, Tschope C . Update on Myocarditis and Inflammatory Cardiomyopathy: Reemergence of Endomyocardial Biopsy. Rev Esp Cardiol (Engl Ed). 2016; 69(2):178-87. DOI: 10.1016/j.rec.2015.10.015. View

15.

Mahfoud F, Ukena C, Kandolf R, Kindermann M, Bohm M, Kindermann I . Blood pressure and heart rate predict outcome in patients acutely admitted with suspected myocarditis without previous heart failure. J Hypertens. 2012; 30(6):1217-24. DOI: 10.1097/HJH.0b013e328352b9ca. View

16.

Charles J, Pollack A, Miller G . Cardiomyopathy. Aust Fam Physician. 2014; 43(5):253. View

17.

OKeefe J, Bhatti S, Bajwa A, DiNicolantonio J, Lavie C . Alcohol and cardiovascular health: the dose makes the poison…or the remedy. Mayo Clin Proc. 2014; 89(3):382-93. DOI: 10.1016/j.mayocp.2013.11.005. View

18.

. Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 2018; 392(10159):1789-1858. PMC: 6227754. DOI: 10.1016/S0140-6736(18)32279-7. View

19.

Leone O, Veinot J, Angelini A, Baandrup U, Basso C, Berry G . 2011 consensus statement on endomyocardial biopsy from the Association for European Cardiovascular Pathology and the Society for Cardiovascular Pathology. Cardiovasc Pathol. 2011; 21(4):245-74. DOI: 10.1016/j.carpath.2011.10.001. View

20.

Arnett D, Blumenthal R, Albert M, Buroker A, Goldberger Z, Hahn E . 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Circulation. 2019; 140(11):e563-e595. PMC: 8351755. DOI: 10.1161/CIR.0000000000000677. View